97579-97-0

Upstream product

• 1885-14-9 phenyl chloroformate 
• 44981-87-5 ethyl 3-(prop-2-en-1-ylamino)propanoate 
• 97579-85-6 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonylethane 
• 97579-89-0 3-(Allyl-phenoxycarbonyl-amino)-2-bromo-propionic acid ethyl ester 
• 97579-93-6 2-(N-allyl-N-phenoxycarbonylamino)-1-ethoxycarbonyl-1-iodoethane 
• 924-73-2 3-amino-propionic acid ethyl ester 

Downstream Products

• 97580-06-8 1-ethoxycarbonyl-3-phenoxycarbonyl-3-azabicyclo<3.1.0>hexane 

Relevant academic research and scientific papers

ATOM TRANSFER CYCLIZATION OF α-HALONITRILE AND α-HALOCARBONYL COMPOUNDS

α-Halonitriles and α-haloesters reacted with internal olefin in the presence of KI to give cyclized products in good yields via radical intermediate. α-Iodonitrile 1b afforded 2b and 2b' merely upon heating.

PALLADIUM CATALYZED ENE-HALOGENOCYCLIZATION OF α-HALOESTER HAVING INTERNAL DOUBLE BOND WITH THE LOW-VALENT METAL COMPLEX

α-Haloester having internal double bond was reacted with a catalytic amount of Pd(Ph3)4 to afford the cyclized product in good yield and the same product was obtained by treatment of ketene silyl acetal with divalent palladium complex.

REACTION OF α-HALOESTER HAVING INTERNAL DOUBLE BOND WITH THE LOW-VALENT METAL COMPLEX

The α-haloester having an internal double bond was allowed to react with a catalytic amount of Pd(PPh3)4 to afford a cyclized product in a fairly good yield and the same product was obtained by treatment with Pd(OAc)2 to ketene silyl acetal.