976-25-0

Upstream product

• 67-56-1 methanol 
• 1743-36-8 1-phenylbut-3-yn-1-ol 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 17488-65-2 4-phenylbut-3-en-2-ol 
• 94-41-7 benzalacetophenone 
• 100-52-7 benzaldehyde 
• 36004-04-3 ethyl (E)-1-phenylbut-1-en-3-ol 
• 1896-62-4 (E)-benzalacetone 
• 97-00-7 1-chloro-2,4-dinitro-benzene 

Downstream Products

• 13789-06-5 3-methyl-5-(p-chlorophenyl)-1-(2',4'-dinitrophenyl)pyrazole 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of some new hydrazones

New hydrazone derivatives were synthesized by the condensation of some selected heteroaromatic hydrazines with appropriate aromatic ketones at high temperature (100 °C). The structures of the synthesized compounds were established by elemental (CHN) and spectral (IR, 1HNMR, and Mass) analysis. The synthesized compounds were screened for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Proteus mirabilis) activities, which reveal that all the compounds possess activity against all the tested organisms.

Regioselective synthesis of 1,3,5-trisubstituted pyrazoles

A new and a simple approach toward synthesis of 1,3,5-trisubstituted pyrazoles from chalcone arylhydrazones via oxidative cyclization has been achieved. 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone was successfully used as an oxidizing agent to give excellen

Larvicidal studies of chalcones and their derivatives

Chalcone (1,3-diphenyl-2-propen-1-one) is considered as the lead compound among all the chalcone type compounds used for the larvicidal studies, as it has the highest toxicity against the larvae of Culex quinquefasciatus. 4-Phenylbut-3-en-2-one, where a methyl group replaces the phenyl group of chalcone, is less active than chalcone; but still has higher activity than other derived compounds except the oxime of the same compound, while 1,5-diphenylpenta-1,4-dien-3-one (in which the lengthening of the acyclic conjugated portion occurs) has almost no activity at 100 ppm at an interval of 24 h. ANOVA and CD values of the compounds show that larvicidal activity of 4-phenylbut-3-en-2-one and its oxime is greater than its phenylhydrazone, which has, however, higher activity than that of semicarbazone of 4-phenylbut-3-en-2- one. On the other hand the activities of 1,5-diphenylpenta-1,4-dien-3-one itself and 2,4-dinitrophenylhydrazone of chalcone and chalcone type compounds are almost nil at 100 ppm concentration at an interval of 24 h at 30 ± 2°C. The probable explanation of the fall of larvicidal activities of these compounds has been presented.

In situ alcohol oxidation-protection reactions

The one-pot conversion of primary and secondary alcohols into phenylhydrazones and 2,4-dintrophenylhydrazones is reported using chromium trioxide supported on silica gel and phenylhydrazines or 2,4- dintrophenylhydrazines under solvent-free conditions. This oxidation arylhydrazone formation reaction has been applied to a range of aliphatic and benzylic alcohols. Copyright Taylor & Francis, Inc.

H2SO4/SiO2 as an efficient catalyst for the preparation of phenylhydrazones and 2,4-dinitrophenylhydrazones under solvent-free conditions

H2SO4 mixed with silica gel (1:1) by weight produces a white powder which is an effective catalyst for the conversion of carbonyl compounds to their corresponding phenylhydrazones and 2,4-dintrophenylhydrazones under solvent-free conditions.