97728-73-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-(4-bromophenyl)-2-methoxyethan-1-one is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its presence of bromine and methoxy groups allows for the creation of a diverse range of compounds with potential therapeutic and pesticidal properties.
Used in Perfume and Flavoring Agent Production:
1-(4-bromophenyl)-2-methoxyethan-1-one is also employed as a reagent in the production of perfumes and flavoring agents. The unique combination of bromine and methoxy groups in its structure contributes to the development of novel and distinct scents and flavors for the fragrance and food industries.

Upstream product

• 1738-36-9 2-methoxyacetonitrile 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 67-56-1 methanol 
• 99-90-1 para-bromoacetophenone 
• 927825-98-7 [1-(4-bromo-phenyl)-vinyloxy]-triisopropyl-silane 
• 99-73-0 para-bromophenacyl bromide 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 1179348-62-9 1-(4-bromophenyl)-2-(2-dimethyl(oxo)-λ⁶-sulfanylidene)ethan-1-one 

Downstream Products

• 1034891-24-1 1-(4-cyclopropylphenyl)-2-methoxyethanone 
• 14966-77-9 6-(4-bromo-phenyl)-3,4-diphenyl-2H-pyran-2-one 

Relevant academic research and scientific papers

Intermolecular C-O Bond Formation with Alkoxyl Radicals: Photoredox-Catalyzed α-Alkoxylation of Carbonyl Compounds

Due to the high reactivity of alkoxyl (RO·) radicals and their propensity to easily undergo β-scission or Hydrogen Atom Transfer (HAT) reactions, intermolecular alkoxylations involving RO· radicals are barely described. We report herein for the first time the efficient intermolecular trapping of alkoxyl radicals by silyl enol ethers. This photoredox-mediated protocol enables the introduction of both structurally simple and more complex alkoxy groups into a wide range of ketones and amides.

Aerobic Photooxidative Synthesis of β-Alkoxy Monohydroperoxides Using an Organo Photoredox Catalyst Controlled by a Base

Transition-metal-free synthesis of β-alkoxy monohydroperoxides via aerobic photooxidation using an acridinium photocatalyst was developed. This method enables the synthesis of some novel hydroperoxides. The peroxide source is molecular oxygen, which is cost-effective and atomically efficient. Magnesium oxide plays an important role as a base in the catalytic system.

Direct Synthesis of α-Alkoxy Ketones by Oxidative C–O Bond Formation

A convenient method to prepare α-alkoxy ketones has been developed by oxidative coupling of aryl methyl ketones and alcohols. With aqueous tert-butyl hydroperoxide (6.0 equiv.) as the oxidant, tetrabutylammonium iodide (20 mol-%) as the catalyst, and TsNHNH2(1.0 equiv.) as the additive, ketones underwent direct alkoxylation to give α-methoxy or α-ethoxy ketones in moderate to good yields.

HETEROCYCLIC COMPOUND

A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like.

HETEROCYCLIC COMPOUND

The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

Iridium-catalyzed X-H insertions of sulfoxonium ylides

Image Persented The unique reactivity of sulfoxonium ylides as a carbene source is described for a variety of X-H bond insertions, taking advantage of a simple, commercially available iridium catalyst. This method has applications in both intra- and intermolecular reactivity, including a practical ring-expansion strategy for lactams. The safety and stability of sulfoxonium ylides recommend them as preferable surrogates to traditional diazo ketones and esters.

Oxidative rearrangements of arylalkanones with 1H-1-hydroxy-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide, a 'green' analog of Koser's reagent

Previous methods for the conversion of arylalkanones to alkyl 2-arylesters by oxidative rearrangement utilized reagents which either produced toxic metal salts or halogenated organics as by-products. In this report, 1H-1-hydroxy-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide (HMBI) is used to effect this useful transformation, where the reduced iodine reagent is water-soluble and readily recycled.

Baker's yeast-mediated reduction of α-hydroxy ketones and derivatives: The steric course of the biotransformation

The results from the baker's yeast-mediated reduction of the acetates 3a- d and the methyl ethers 5a-d were compared with the same biotransformation which converts the α-hydroxy ketones 1a-d into the (R)-diols 2a-d (90- 98%ee); the acetates 3a-d afford the (S)-monoacetates 4a-d (72-94% ee) and the methyl ethers 5a-d are reduced to the (R)-monoethers 6a-d (64-76% ee).