97744-29-1

Upstream product

• 130160-97-3 2,6-dimethyl-4-(2'-chlorophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester 
• 43067-01-2 3,5-bis(methoxycarbonyl)-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine 
• 73257-43-9 dimethyl 2,6-dimethyl-4-(2-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 71653-63-9 Riodipine 
• 112010-45-4 Methyl 2,4-dimethyl-5-oxo-3,10b-dihydro-5H-<1>benzopyrano<3,4-c>pyridine-1-carboxylate 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 90-02-8 salicylaldehyde 
• 67-56-1 methanol 
• 112010-44-3 2,4-Dimethyl-5-oxo-5H-<1>benzopyrano<3,4-c>pyridine-1-carboxylic acid 
• 186581-53-3 diazomethane 
• 135-02-4 ortho-anisaldehyde 
• 112010-43-2 Dimethyl 4-(2-methoxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate 
• 105-45-3 acetoacetic acid methyl ester 
• 97744-33-7 3,5-dimethoxycarbonyl-2,6-dimethyl-4-(o-difluoromethoxyphenyl)-pyridine 

Relevant academic research and scientific papers

Photochemistry of Hantzsch 1,4-dihydropyridines and pyridines

The photochemistry of some Hantzsch 4-phenyl-1,4-dihydropyridines bearing a substituent on the phenyl ring (the three isomeric chloro derivatives and the 4′-nitro derivative) has been studied. All of these compounds underwent inefficient aromatization to

SYNTHESIS, OXIDATION AND CLAISEN REARRANGEMENT OF 4-(ALLYLOXY)PHENYL-1,4-DIHYDROPYRIDINES AND -PYRIMIDINES

1,4-Dihydropyridines and -pyrimidines can be oxidized conveniently to pyridine and pyrimidine with active MnO2 with or without cleavage of the 4-substituent.In a TiCl4 catalyzed reaction ortho-Claisen rearrangement takes place with both 4-(2-allyoxy)pheny

Synthesis of Dialkyl 2-(2-Hydroxyphenyl)-4,6-dimethyl-1,2-dihydropyridine-3,5-dicarboxylates and Alkyl 2,4-Dimethyl-5-oxo-5H-benzopyrano-pyridine-3-carboxylates

The reaction of 2-hydroxybenzaldehydes with 3-oxobutanoic esters and excess ammonia in acetic acid at room temperature yields dialkyl 2-(2-hydroxyphenyl)-4,6-dimethyl-1,2-dihydropyridine-3,5-dicarboxylates and their 2-(3,5-dialkoxycarbonyl-4,6-dimethyl-1,2,3-trihydropyridinium-2-yl)-phenoxide zwitterions.Mild oxidation of these compounds is accompanied by lactonisation, with formation of alkyl 2,4-dimethyl-5-oxo-5H-benzopyranopyridine-3-carboxylates, which had previously been incorrectly formulated.Reaction of other o-substituted benzaldehydes with alkyl 3-aminocrotonates in acetic acid at room temperature also yields dialkyl 2-aryl-4,6-dimethyl-1,2-dihydropyridine-3,5-dicarboxylates, as well as the normal 1,4-dihydropyridine Hantzsch esters.

Pharmacokinetics and metabolism of ryodipine in rats

2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydr opyridine (ryodipine, PP-1466) on oral administration in the form of a suspension with Tween (polysorbate) 80 addition is comparatively rapidly absorbed in the gastro-intestinal tra