175277-96-0

Usage

Uses

Used in Pharmaceutical Industry:
4-CYANO-2-(TRIFLUOROMETHYL)ACETANILIDE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of biologically active compounds. Its unique structure allows for the creation of a variety of medicinal agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CYANO-2-(TRIFLUOROMETHYL)ACETANILIDE is utilized as an intermediate in the production of agrochemicals, playing a role in the development of substances that can protect crops and enhance agricultural productivity.
Used as a Reagent in Organic Synthesis:
4-CYANO-2-(TRIFLUOROMETHYL)ACETANILIDE is employed as a reagent in organic synthesis, where it aids in the formation of new chemical entities through various chemical reactions.
Used in Dyes and Pigments Production:
4-CYANO-2-(TRIFLUOROMETHYL)ACETANILIDE is also used as a raw material in the production of dyes and pigments, contributing to the coloration and properties of these substances in various applications.

InChI:InChI=1/C10H7F3N2O/c1-6(16)15-9-3-2-7(5-14)4-8(9)10(11,12)13/h2-4H,1H3,(H,15,16)

Upstream product

• 88-17-5 2-(trifluoromethyl)benzenamine 
• 2926-29-6 Langlois reagent 
• 35704-19-9 N-(4-cyanophenyl)acetamide 
• 97760-97-9 4-iodo-2-(trifluoromethyl)aniline 
• 544-92-3 copper(I) cyanide 
• 97760-98-0 N-(4-iodo-2-(trifluoromethyl)phenyl)acetamide 

Downstream Products

• 400-76-0 4-amino-3-(trifluoromethyl)benzoic acid 
• 688020-69-1 ethyl 4-amino-3-(trifluoromethyl)benzoate 
• 97804-09-6 diethyl 2-(4-amino-3-bromo-5-trifluoromethyl-benzoyl)-malonate 
• 97776-04-0 diethyl 2-(4-amino-3-chloro-5-trifluoromethyl-benzoyl)-malonate 
• 97776-05-1 4-amino-3-bromo-5-trifluoromethyl-benzoic acid 
• 95656-52-3 4-amino-3-chloro-5-(trifluoromethyl)benzoic acid 
• 63498-20-4 4-amino-3-bromo-5-trifluoromethyl-benzoyl chloride 
• 63498-15-7 4-amino-3-chloro-5-trifluoromethyl-benzoyl chloride 
• 54295-65-7 1-(4'-Amino-3'-trifluoromethyl-phenyl)-2-tert-butylamino-ethanol 
• 772281-16-0 N-[4-(2-tert-Butylamino-1-hydroxy-ethyl)-2-trifluoromethyl-phenyl]-acetamide 
• 97760-75-3 N-(4-acetyl-2-(trifluoromethyl)phenyl)acetamide 

Relevant academic research and scientific papers

Visible-light-induced Pd-catalyzed: Ortho -trifluoromethylation of acetanilides with CF3SO2Na under ambient conditions in the absence of an external photocatalyst

A visible-light-induced Pd-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na was developed. The reaction proceeded smoothly at room temperature in air without any external photocatalyst or additive, providing the desired products in moderate to good yields with good functional group tolerance and regioselectivity.

Preparation 2-trifluoromethyl-4-substituted aniline compounds

The invention relates to a method for preparing 2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide. The method for preparing the2-trifluoromethyl-4-substituted phenylamine and 2-trifluoromethyl-4-substituted acetanilide comprises the following main step: in the presence of sodium trifluoromethanesulfonate and tert-butyl hydroperoxide but no metal salt catalyst and under the stirring condition, maintaining a 4-substituted phenylamine compound (concrete structure shown in a formula II is described in the specification) in a reaction medium of mixture composed of dichloromethane and water at the temperature of 0-25 DEG C for 72-120 hours, so that the 2-trifluoromethyl-4-substituted phenylamine target product is obtained. The preparation method provided by the invention has potential commercial value.

Copper-free direct C-H trifluoromethylation of acetanilides with sodium trifluoromethanesulfinate

A copper-free direct C-H ortho trifluoromethylation of electron-deficient 4-substituted acetanilides using Langlois reagent (NaSO2CF3) as the CF3 source in the presence of tert-butyl hydroperoxide (tBuOOH, TBHP) was developed.

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.