97819-36-8Relevant academic research and scientific papers
Enantioselective synthesis of 7H-pyrano[2,3-d]thiazoles via squaramide-catalyzed [2+4] annulation of malononitrile and 5-ylidenethiazol-4-ones
Cui, Lei,Wang, Youming,Zhou, Zhenghong
, p. 1056 - 1061 (2016)
An efficient catalytic asymmetric synthesis of 7H-pyrano[2,3-d]thiazoles has been developed on the basis of the organocatalyzed [4+2] annulation of malononitrile and 5-ylidenethiazol-4-ones. Under the catalysis of a bifunctional squaramide derived from L-tert-leucine, the reaction of malononitrile and a wide range of 5-ylidenethiazol-4-ones ran smoothly to afford the corresponding structurally diverse 7H-pyrano[2,3-d]thiazole derivatives in good yields (70–94%) and with moderate to excellent enantioselectivities (43–>99% ee).
