92795-17-0Relevant academic research and scientific papers
Organophosphane-catalyzed direct β-acylation of 4-arylidene pyrazolones and 5-arylidene thiazolones with acyl chlorides
Khairnar, Pankaj V.,Su, Yin-Hsiang,Chen, Yung-Chang,Edukondalu, Athukuri,Chen, Yi-Ru,Lin, Wenwei
supporting information, p. 6868 - 6872 (2020/09/15)
An efficient method for the direct β-acylation of arylidene pyrazolones and thiazolones with acyl chlorides in the presence of a base catalyzed by organophosphanes is reported. A variety of functionalized 4-arylidene pyrazolone and 5-arylidene thiazolone derivatives were prepared under metal-free and mild conditions via a tandem phospha-Michael addition/O-acylation/intramolecular cyclization/rearrangement sequence. Our mechanistic investigations revealed that the reaction is highly stereospecific to provide exclusively cis-isomers, and the methodology can also be scaled up with similar efficacy.
Enantioselective Construction of Spiro[chroman-thiazolones]: Bifunctional Phosphonium Salt-Catalyzed [2+4] Annulation between 5-Alkenyl Thiazolones and ortho-Hydroxyphenyl-Substituted para-Quinone Methides
Tan, Jian-Ping,Zhang, Hongkui,Jiang, Zhiyu,Chen, Yuan,Ren, Xiaoyu,Jiang, Chunhui,Wang, Tianli
supporting information, p. 1058 - 1063 (2020/01/02)
The enantioselective formal [2+4] annulation of 5-alkenyl thiazolones with hydroxyl-substituted para-quinone methides was disclosed by dipeptide-based phosphonium salt catalysts. A wide range of functionalized spiro-chroman-thiazolone molecules bearing three contiguous 3° and/or 4° stereocenters were readily constructed in high yields with excellent stereoselectivities (>20:1 dr and up to >99.9% ee) under low catalyst loading and mild reaction conditions. The practicality and utility of this protocol were demonstrated by the scaled-up preparation and elaborations of product. (Figure presented.).
Thiazolo [2,3-b] oxazolone compound and preparation method and application thereof
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Paragraph 0084-0086, (2019/12/10)
The invention provides a compound shown in a formula I, or a salt thereof, or a stereoisomer thereof; R1 is selected from 3 and 8-element unsaturated cycloalkyl and 3 and 8-element unsaturated heterocyclic group; R2 is selected from hydrogen, C1-C8 alkyl
Oxidative N-heterocyclic carbene catalyzed stereoselective annulation of simple aldehydes and 5-alkenyl thiazolones
Lin, Li,Yang, Yuhong,Wang, Mei,Lai, Luhao,Guo, Yarong,Wang, Rui
supporting information, p. 8134 - 8137 (2015/05/20)
A highly diastereoselective annulation of simple aldehydes and 5-alkenyl thiazolones, via oxidative NHC catalysis has been developed. This strategy provides facile access to a diverse library of functionalized chiral thiazolo pyrones. Aerobic oxygen can a
