97945-32-9Relevant academic research and scientific papers
S(RN)1 synthesis of new 5-nitroimidazoles highly active against protozoa and anaerobes
Vanelle,Crozet,Maldonado,Barreau
, p. 167 - 178 (2007/10/02)
1-Methyl-2-chloromethyl-5-nitroimidazole reacts by an S(RN)1 mechanism with various aliphatic, cyclic or heterocyclic nitronate anions to afford, in high yields, new 5-nitroimidazoles bearing a trisubstituted ethylenic double bond at the 2 position. Some of these compounds are as active as metronidazole in vitro and in vivo against protozoa and anaerobic bacteria. Structure-activity relationships are discussed.
REACTIONS SRN1 EN SERIE HETEROCYCLIQUE: II. REACTIVITE DU METHYL-1 CHLOROMETHYL-2 NITRO-5 IMIDAZOLE.
Crozet, Michel P.,Surzur, Jean-Marie,Vanelle, Patrice,Ghiglione, Claude,Maldonado, Jose
, p. 1023 - 1026 (2007/10/02)
1-Methyl-2-chloromethyl-5-nitroimidazole reacts with tertiary nitronate anions in excess to afford in high yields the previously unknown 1-methyl-5-nitro-imidazoles bearing a trisubstituted ethylenic double bond in the 2 position.These compounds are ascri
