6343-65-3

Basic information

• Product Name: (2S)-2-nitrobicyclo[2.2.1]heptane
• CAS NO: 6343-65-3
• Molecular Formula: C₇H₁₁NO₂
• Molecular Weight: 141.1677
• Mol File: 6343-65-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 226.721°C at 760 mmHg
• Flash Point: 98.744°C
• Density: 1.165g/cm³
• Vapor Pressure: 0.081mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: (2S)-2-nitrobicyclo[2.2.1]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-nitrobicyclo[2.2.1]heptane(6343-65-3)
• EPA Substance Registry System: (2S)-2-nitrobicyclo[2.2.1]heptane(6343-65-3)

Safety Data

• Hazardous Substances Data: 6343-65-3(Hazardous Substances Data)

Usage

General Description

(2S)-2-nitrobicyclo[2.2.1]heptane is a chemical compound that belongs to the class of bicyclic compounds. It consists of a bicyclic ring system with a nitro group attached to one of the carbon atoms in the ring. (2S)-2-nitrobicyclo[2.2.1]heptane has a chiral center, with the (2S) configuration indicating that the nitro group is attached to the second carbon atom in the ring in the S configuration. Despite its simple structure, (2S)-2-nitrobicyclo[2.2.1]heptane has potential applications in organic synthesis and as a building block for more complex chemical compounds. Its unique structure and chiral nature make it an interesting target for chemical research and development.

Upstream product

• 874-44-2 5-endo-nitrobicyclo<2.2.1>hept-2-ene 
• 64-19-7 acetic acid 
• 279-23-2 norbornene 
• 6343-65-3 endo-2-nitronorbornane 
• 7242-92-4 exo-2-aminonorbornane 
• 74087-85-7 3,3-dimethyldioxirane 
• 65481-69-8 bicyclo[2.2.1]heptan-2-endo-amine hydrochloride 

Downstream Products

• 497-38-1 Norbornan-2-on 
• 497-38-1 2-norbornanone 
• 6343-65-3 exo-2-nitronorbornane 
• 7242-92-4 exo-2-aminonorbornane 
• 3281-03-6 norcamphor 2,4-dinitrophenylhydrazone 
• 158506-27-5 endo-2-Nitro-2-fluoronorbornane 
• 158506-27-5 exo-2-Nitro-2-fluoronorbornane 
• 97945-32-9 (E)-1-methyl 2-(2-norbornanylidenemethyl) 5-nitroimidazole 

Relevant articles and documents

SRN1 reactions in the nitrobenzo[1,3]dioxole series

5-Chloromethyl-6-nitrobenzo[1,3]dioxole has been shown to react with 2-nitropropane anion to give C-alkylation by an SRN1 mechanism. The reaction was extended to various aliphatic, cyclic, and heterocyclic nitronate anions, leading to a new series of nitrobenzo[1,3]dioxole derivatives.

S(RN)1 synthesis of new 5-nitroimidazoles highly active against protozoa and anaerobes

1-Methyl-2-chloromethyl-5-nitroimidazole reacts by an S(RN)1 mechanism with various aliphatic, cyclic or heterocyclic nitronate anions to afford, in high yields, new 5-nitroimidazoles bearing a trisubstituted ethylenic double bond at the 2 position. Some of these compounds are as active as metronidazole in vitro and in vivo against protozoa and anaerobic bacteria. Structure-activity relationships are discussed.

Oxidation of Primary Amines by Dimethyldioxirane

Dimethyldioxirane oxidizes primary amines rapidly, and generally in high yield, to the corresponding nitro compounds.The method can also be used to syntesize polynitro compounds.