6343-65-3

Usage

Uses

Used in Organic Synthesis:
(2S)-2-nitrobicyclo[2.2.1]heptane is used as a building block in organic synthesis for the creation of more complex chemical compounds. Its unique structure and chiral nature make it a valuable component in the synthesis of various organic molecules.
Used in Chemical Research and Development:
(2S)-2-nitrobicyclo[2.2.1]heptane is used as a target in chemical research and development due to its potential applications in creating new and innovative chemical compounds. Its unique structure and chiral nature provide opportunities for further exploration and discovery in the field of chemistry.

Upstream product

• 74087-85-7 3,3-dimethyldioxirane 
• 65481-69-8 bicyclo[2.2.1]heptan-2-endo-amine hydrochloride 
• 874-44-2 5-endo-nitrobicyclo<2.2.1>hept-2-ene 
• 64-19-7 acetic acid 
• 279-23-2 norbornene 
• 6343-65-3 endo-2-nitronorbornane 
• 7242-92-4 exo-2-aminonorbornane 

Downstream Products

• 497-38-1 Norbornan-2-on 
• 497-38-1 2-norbornanone 
• 6343-65-3 exo-2-nitronorbornane 
• 7242-92-4 exo-2-aminonorbornane 
• 158506-27-5 endo-2-Nitro-2-fluoronorbornane 
• 158506-27-5 exo-2-Nitro-2-fluoronorbornane 
• 97945-32-9 (E)-1-methyl 2-(2-norbornanylidenemethyl) 5-nitroimidazole 
• 3281-03-6 norcamphor 2,4-dinitrophenylhydrazone 

Relevant academic research and scientific papers

SRN1 reactions in the nitrobenzo[1,3]dioxole series

5-Chloromethyl-6-nitrobenzo[1,3]dioxole has been shown to react with 2-nitropropane anion to give C-alkylation by an SRN1 mechanism. The reaction was extended to various aliphatic, cyclic, and heterocyclic nitronate anions, leading to a new series of nitrobenzo[1,3]dioxole derivatives.

Fluorination of Nitro Compounds with Acetyl Hypofluorite

Various types of nitro derivatives are fluorinated to form the CFNO2 moiety in very good yields using acetyl hypofluorite (AcOF).The corresponding nitro anion, preferably prepared with NaOMe, is added quickly to a cold (-75 deg C) CFCl3 solution of AcOF,

S(RN)1 synthesis of new 5-nitroimidazoles highly active against protozoa and anaerobes

1-Methyl-2-chloromethyl-5-nitroimidazole reacts by an S(RN)1 mechanism with various aliphatic, cyclic or heterocyclic nitronate anions to afford, in high yields, new 5-nitroimidazoles bearing a trisubstituted ethylenic double bond at the 2 position. Some of these compounds are as active as metronidazole in vitro and in vivo against protozoa and anaerobic bacteria. Structure-activity relationships are discussed.

Synthesis by the S(RN)1 reaction of a new series of imidazo[1,2-a]pyridine derivatives with pharmacological potentialities

The study of S(RN)1 reaction between 2-chloromethyl-3-nitroimidazo[1,2-a] pyridine and 2-nitropropane salts has been extended to various aliphatic, cyclic and heterocyclic nitronate anions. From C-alkylation products, base-promoted nitrous acid elimination afforded new potential pharmacological derivatives with a trisubstituted double bond at the 2 position.

Oxidation of Primary Amines by Dimethyldioxirane

Dimethyldioxirane oxidizes primary amines rapidly, and generally in high yield, to the corresponding nitro compounds.The method can also be used to syntesize polynitro compounds.