98015-53-3

Basic information

• Product Name: (+/-)-1,2,2,2-TETRACHLOROETHYL CHLOROFORMATE
• Synonyms: (+/-)-1,2,2,2-TETRACHLOROETHYL CHLOROFORMATE;Tetra Chloro-Ethyl chloroformate;(±)-1,2,2,2-Tetrachloroethyl chloroformate,98%;(#1)-1,2,2,2-Tetrachloroethyl chloroformate;Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester
• CAS NO: 98015-53-3
• Molecular Formula: C₃HCl₅O₂
• Molecular Weight: 246.3
• Mol File: 98015-53-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 78 °C15 mm Hg(lit.)
• Flash Point: 193 °F
• Appearance: /
• Density: 1.61 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.633mmHg at 25°C
• Refractive Index: n20/D 1.482(lit.)
• Storage Temp.: Refrigerator (+4°C)
• CAS DataBase Reference: (+/-)-1,2,2,2-TETRACHLOROETHYL CHLOROFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-1,2,2,2-TETRACHLOROETHYL CHLOROFORMATE(98015-53-3)
• EPA Substance Registry System: (+/-)-1,2,2,2-TETRACHLOROETHYL CHLOROFORMATE(98015-53-3)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3390 6.1/PG 1
• WGK Germany: 3
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 98015-53-3(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester is used in the synthesis of Doxorubicin (D558000), is used as an antineoplastic. Also used in the synthesis of metabolites of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.

InChI:InChI=1/C3HCl5O2/c4-1(3(6,7)8)10-2(5)9/h1H/t1-/m0/s1

Upstream product

• 75-44-5 phosgene 
• 75-87-6 chloral 

Downstream Products

• 142478-57-7 8-oxo-7-phenylacetylamino-3-(2,3,3,3-tetrachloro-propionyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 805231-36-1 (6R,7R)-7-Allyloxycarbonylamino-8-oxo-3-(1,2,2,2-tetrachloro-ethoxycarbonyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 153756-88-8 4-acetamidophenyl 1,2,2,2-tetrachloroethyl carbonate 
• 107960-03-2 Carbonic acid 1,2,2,2-tetrachloro-ethyl ester 2,4,6-trichloro-phenyl ester 
• 108034-67-9 1,2,2,2-tetrachloroethyl 2,4,5-trichlorophenyl carbonate 
• 154044-76-5 2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate 
• 107960-05-4 1,2,2,2-tetrachloroethyl pentafluorophenyl carbonate 
• 160651-93-4 2-(2-methoxycarbonylpropyl)-1',2',2',2'-tetrachloroethyl-carbonate 
• 107960-04-3 pentachlorophenyl 1,2,2,2-tetrachloroethyl carbonate 
• 107960-06-5 1,2,2,2-tetrachloroethyl 4-nitrophenyl carbonate 
• 107960-07-6 Carbonic acid 2,4-dinitro-phenyl ester 1,2,2,2-tetrachloro-ethyl ester 
• 107960-02-1 1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate 

Relevant articles and documents

2,2-Dichlorovinyl Chloroformate

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1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate: A Simple and Efficient Reagent for the tert-Butoxycarbonylation of Amines and Amino Acids

The reaction of 1-chloroalkyl carbonates with amines affords good yields of the corresponding carbamates.Application to the BOC protection of amino acids is described.