154044-76-5

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 98015-53-3 1,2,2,2-tetrachloroethyl chloroformate 
• 154044-75-4 2-methyl-1-(4-methoxyphenyl)methoxy-2-propanol 

Downstream Products

• 160651-89-8 N-de-t-butoxycarbonyl-N-2-(1-hydroxy-2-methyl)propyloxycarbonyl-7,10-O-diTroc-docetaxel 
• 154044-57-2 RPR 104952 
• 154044-74-3 N-de-t-butoxycarbonyl-N-2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyloxycarbonyl-7,10-O-diTroc-docetaxel 

Relevant academic research and scientific papers

CETP INHIBITORS

Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. I

Partial synthesis of major human metabolites of docetaxel

The structures and synthesis of the four major human metabolites of docetaxel are reported. These metabolites, i.e. compounds 3, 4a,b and 5, are side-chain oxidation derivatives. They were prepared by partial synthesis from the previously described amino-taxoid 8 using mixed-carbonates as acylation reagents. In vitro biological activities are detailed.