98035-61-1

Usage

Chemical Properties

White to off-white powder

Upstream product

• 33477-43-9 Z-L-valylglycinamide 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 3392-12-9 Boc-Val-ONSu 
• 165900-96-9 Boc-Val-Gly-NH₂ 
• 26464-05-1 2-bromo-3-methyl-butyryl bromide 
• 871878-30-7 N-(α-bromo-isovaleryl)-glycine amide 

Downstream Products

• 147424-36-0 Z-Val-Val-Gly-NH₂ 
• 1025831-19-9 (S)-3-((S)-2-{(R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-N-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid benzyl ester 
• 1025941-24-5 (S)-3-((S)-2-{(R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-N-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid tert-butyl ester 
• 147424-43-9 Z-Asp(OtBu)-Val-Val-Gly-NH₂ 
• 147424-50-8 Z-Val-Asp(OtBu)-Val-Gly-NH₂ 
• 122752-15-2 deltorphin C 
• 132125-58-7 H-Tyr-D-Ala-Phe-Val-Asp-Val-Gly-NH₂ 
• 165901-09-7 Z-Tyr(SO₃H)-D-Ala-Phe-Asp(OBzl)-Val-Val-Gly-NH₂ 
• 165901-08-6 Z-Tyr-D-Ala-Phe-Asp(OBzl)-Val-Val-Gly-NH₂ 
• 165901-05-3 Boc-D-Ala-Phe-Asp(OBzl)-Val-Val-Gly-NH₂ 
• 165901-02-0 Boc-Phe-Asp(OBzl)-Val-Val-Gly-NH₂ 
• 165901-06-4 H-D-Ala-Phe-Asp(OBzl)-Val-Val-Gly-NH₂ 
• 165901-03-1 H-Phe-Asp(OBzl)-Val-Val-Gly-NH₂ 
• 147424-44-0 Boc-Asp(OBzl)-Val-Val-Gly-NH₂ 

Relevant academic research and scientific papers

2,2-Dimethyl-2-(o-nitrophenyl)acetyl (DMNA) as an assisted cleavage protecting group for amines

2,2-Dimethyl-2-(o-nitrophenyl)acetyl group (DMNA) was explored as an assisted cleavage protecting group for amines and a one-step deprotection condition was developed for its efficient removal using hydrogenation in the presence of Pd-C or PtO2 catalyst and 10% HOAc in MeOH. DMNA was found to be especially useful for the synthesis of gem-diamino compounds using Hofmann rearrangement.

Synthesis and opioid activity of tyrosine sulfate containing dermorphin and deltorphin peptides

To study the effect of the sulfate ester moiety on the opioid activity, we prepared two tyrosine sulfate-(Tyr(SO3H))-containing dermorphin and deltorphin peptides. Their activities were determined in binding studies based on displacement of μ-

Unique sequence in deltorphin C confers structural requirement for δ opioid receptor selectivity

A series of deltorphin C (H-Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2) analogues were synthesized to assess the consequences of changing anionic and hydrophobic residues on δ receptor selectivity.Analogues with altered C-terminal groups, inverted sequences, or es