98056-47-4

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 4255-62-3 4,4-dimethylcyclohexane-1-one 
• 456-56-4 phenyl trifluoromethylsulfide 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 1073-13-8 4,4-dimethylcyclohexenone 

Downstream Products

• 503112-74-1 4,4-dimethyl-cyclohex-1-enecarboxylic acid (2-hydroxy-phenyl)-methyl-amide 
• 1203460-33-6 1‐iodo‐4,4‐dimethylcyclohex‐1‐ene 
• 100794-17-0 1,1-Dimethyl-4-phenyl-cyclohexan 
• 1449115-48-3 1-ethynyl-4,4-dimethylcyclohex-1-ene 
• 1449115-39-2 4-(4,4-dimethylcyclohex-1-en-1-yl)-1-tosyl-1H-1,2,3-triazole 
• 1449115-09-6 6,6-dimethyl-1-tosyl-4,5,6,7-tetrahydro-1H-indole 
• 859217-67-7 2-(4,4-dimethylcyclohex-1-ene-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 329015-44-3 trifluoro-methanesulfonic acid 2-[(4,4-dimethyl-cyclohex-1-enecarbonyl)-methyl-amino]-phenyl ester 

Relevant academic research and scientific papers

Alkenylation and Arylation of Peptides via Ni-Catalyzed Reductive Coupling of α- C-Tosyl Peptides with Csp2Triflates/Halides

A Ni-catalyzed reductive cross-coupling between α-C-tosyl peptides and Csp2 triflates/halides has been developed. This protocol enables the formation of various unnatural di- and tripeptides containing vinyl and aryl side chains, and it expands the applications of Ni-catalyzed reductive cross-coupling in late-stage diversification of peptides.

N-(PYRIDIN-2-YLSULFONYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A CFTR MEDIATED DISEASE

The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds of formula (1) as claimed in claim 1, their use in the treatment or the prevention of viral disorders, including HIV. (Formula I)

Origin of stereocontrol in the construction of the 12-oxatricyclo[6.3.1. 02,7]dodecane ring system by Prins-pinacol reactions

(Chemical Equation Presented) Polycyclic products containing the 12-oxatricyclo[6.3.1.02,7]dodecane moiety having either the trans (8a-e) or cis (9a-e) relative configuration of the oxacyclic bridge and the cis angular substituents are formed s

1,2-Di(cyclic)substituted benzene compounds

In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome; rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.

4-CARBOX PYRAZOLE DERIVATES USEFUL AS ANTI-VIRAL AGENTS

Novel antiviral compounds of Formula (I) : wherein: A represents hydroxy; R1 represents aryl, heteroaryl bonded through a ring carbon atom, or heterocyclyl bonded through a ring carbon atom, C1-6alkyl or -C5-9cycloalkyl, each of which may be optionally su