98081-75-5

Upstream product

• 1816-92-8 Methyl azidoacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 4504-27-2 1-azidopropan-2-one 

Downstream Products

• 98081-83-5 methyl 6-methoxy-1H-indole-2-carboxylate 
• 138278-76-9 dimethyl 2,6-bis(4-methoxyphenyl)pyrimidine-4,5-dicarboxylate 
• 856899-98-4 methyl 2-dihydroxy-3-(4-methoxyphenyl)propanoate 
• 55301-58-1 2-hydroxy-3-(4-methoxyphenyl)propionic acid methyl ester 
• 1443676-80-9 3-(4-methoxyphenyl)-N-methyl-2-((triphenylphosphanilydene)amino)acrylamide 
• 1443676-92-3 (Z)-5-(4-hydroxybenzylidene)-3-methyl-3,5-dihydro-4H-imidazol-4-one 
• 1443676-91-2 (Z)-4-(4-hydroxybenzylidene)-1-methyl-2-trifluoromethyl-1H-imidazol-5(4H)-one 
• 1443676-89-8 (Z)-5-(4-hydroxybenzylidene)-2-isopropyl-3-methyl-3,5-dihydro-4H-imidazol-4-one 
• 1443676-88-7 (Z)-5-(4-hydroxybenzylidene)-3-methyl-2-propyl-3,5-dihydro-4H-imidazol-4-one 
• 1443676-87-6 (Z)-2-ethyl-5-(4-hydroxybenzylidene)-3-methyl-3,5-dihydro-4H-imidazol-4-one 
• 200940-00-7 (Z)-4-(4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one 
• 1443676-86-5 (Z)-4-(4-methoxybenzylidene)-1-methyl-1H-imidazol-5(4H)-one 
• 1443676-85-4 (Z)-4-(4-methoxybenzylidene)-1-methyl-2-trifluoromethyl-1H-imidazol-5(4H)-one 
• 1443676-84-3 (Z)-4-(4-methoxybenzylidene)-1-methyl-2-propyl-1H-imidazol-5(4H)-one 

Relevant academic research and scientific papers

A telescoped protocol for the synthesis of new pyrrolo [3,4-d]pyridazinones by cascade reactions

A new one-pot method, for the synthesis of polysubstituted pyrrolo[3,4-d]pyridazinones, is presented. The protocol consists in cascade reactions performed in the same media: (i) the thermal in situ pyrrole formation by the reaction of vinyl azides with 1,

A synthetic approach to GFP chromophore analogs from 3-azidocinnamates. Role of methyl rotors in chromophore photophysics

We have suggested a novel combinatorial approach for synthesis of otherwise inaccessible GFP chromophore analogs, and studied the influence of aliphatic substituents on their pH-dependent spectral properties. We found that the demethylation at C or N posi

Extending the versatility of the Hemetsberger-Knittel indole synthesis through microwave and flow chemistry

Microwave, flow and combination methodologies have been applied to the synthesis of a number of substituted indoles. Based on the Hemetsberger-Knittel (HK) process, modifications allow formation of products rapidly and in high yield. Adapting the methodology allows formation of 2-unsubstituted indoles and derivatives, and a route to analogs of the antitumor agent PLX-4032 is demonstrated. The utility of the HK substrates is further demonstrated through bioconjugation and subsequent ring closure and via Huisgen type [3+2] cycloaddition chemistry, allowing formation of peptide adducts which can be subsequently labeled with fluorine tags.

Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists

A series of benzoxazole or benzothiazole containing indole analogs, 6-alkoxyindole-2-carboxylic acids and 5-alkoxy-3-indolylacetic acids, were synthesized as novel candidates of PPARγ/δ dual agonists and their ligand activities for PPAR subtypes (α, γ, an

[Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source

The syntheses of alkaloids including indoles, indolines, tetrahydroquinolines, dihydroquinazolinones and quinazolinones have been accomplished in moderate to excellent yields via [Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation using aryl azides as nitrogen source.

General and easy access to 11-substituted 4-hydroxy-2,3,4,5-tetrahydro[1,4] diazepino[1,2-a]indol-1-one derivatives

An efficient route to prepare the 4-hydroxy-2,3,4,5-tetrahydro[1,4] diazepino[1,2-a]indol-1-one scaffold is described. The key reactions of the synthesis are an iodolactonisation followed by a lactone-to-lactam rearrangement. Various 11-substituted deriva

Synthesis of phenylalanine analogs

A straight forward synthesis of phenylalanine analogs is described. Cerium ammonium nitrate (CAN) mediated addition of azide to cinnamicester, followed by reaction with sodium acetate aff orded the α-azidocinnamate in moderate yield. Hydrogenation of α-azidocinnamate, followed by BOC, CBZ or Fmoc protection gave phenylalanine analogs. A new approach for synthesizing racemic p-boronophenylalanine analog was also explored.

AMINO ACIDS AS SYNTHONS FOR HETEROCYCLES. FORMATION OF 1,2,4-TRIAZINE DERIVATIVES

Transformation of the amino group of amino acids into an amidine and subsequent treatment with hydrazine leads to 1,2,4-triazine-6(1H)-ones.The method described is a new synthetic approach.Unsaturated amino acids gave imidazol-5-one derivatives after the