98081-75-5

Basic information

• Product Name: 2-Propenoic acid, 2-azido-3-(4-methoxyphenyl)-, methyl ester
• CAS NO: 98081-75-5
• Molecular Formula: C11H11N3O3
• Molecular Weight: 233.227
• Mol File: 98081-75-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-azido-3-(4-methoxyphenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-azido-3-(4-methoxyphenyl)-, methyl ester(98081-75-5)
• EPA Substance Registry System: 2-Propenoic acid, 2-azido-3-(4-methoxyphenyl)-, methyl ester(98081-75-5)

Safety Data

• Hazardous Substances Data: 98081-75-5(Hazardous Substances Data)

Upstream product

• 4504-27-2 1-azidopropan-2-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 1816-92-8 Methyl azidoacetate 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 

Downstream Products

• 128070-29-1 (E)-3-(4-Methoxy-phenyl)-2-(2,2,2-trifluoro-acetylamino)-acrylic acid methyl ester 
• 98081-83-5 methyl 6-methoxy-1H-indole-2-carboxylate 
• 1372411-82-9 methyl 5-hydroxy-4-(4-methoxy-phenyl)-1-oxo-2,5-dihydro-1H-benzo[c]azepine-3-carboxylate 
• 1372411-98-7 methyl 4-(4-methoxy-phenyl)-1,5-dioxo-2,5-dihydro-1H-benzo[c]azepine-3-carboxylate 
• 16732-73-3 6-Methoxyindole-2-carboxylic acid 
• 3189-13-7 6-methoxylindole 
• 1443676-81-0 (Z)-4-(4-methoxybenzylidene)-1-methyl-2-isopropyl-1H-imidazol-5(4H)-one 
• 1443676-82-1 (Z)-4-(4-methoxybenzylidene)-1-methyl-2-tert-butyl-1H-imidazol-5(4H)-one 
• 101820-96-6 (Z)-5-(4-methoxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one 
• 1443676-83-2 (Z)-4-(4-methoxybenzylidene)-1-methyl-2-ethyl-1H-imidazol-5(4H)-one 
• 1443676-84-3 (Z)-4-(4-methoxybenzylidene)-1-methyl-2-propyl-1H-imidazol-5(4H)-one 
• 1443676-85-4 (Z)-4-(4-methoxybenzylidene)-1-methyl-2-trifluoromethyl-1H-imidazol-5(4H)-one 
• 1443676-86-5 (Z)-4-(4-methoxybenzylidene)-1-methyl-1H-imidazol-5(4H)-one 
• 200940-00-7 (Z)-4-(4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one 

Relevant articles and documents

A telescoped protocol for the synthesis of new pyrrolo [3,4-d]pyridazinones by cascade reactions

A new one-pot method, for the synthesis of polysubstituted pyrrolo[3,4-d]pyridazinones, is presented. The protocol consists in cascade reactions performed in the same media: (i) the thermal in situ pyrrole formation by the reaction of vinyl azides with 1,

Extending the versatility of the Hemetsberger-Knittel indole synthesis through microwave and flow chemistry

Microwave, flow and combination methodologies have been applied to the synthesis of a number of substituted indoles. Based on the Hemetsberger-Knittel (HK) process, modifications allow formation of products rapidly and in high yield. Adapting the methodology allows formation of 2-unsubstituted indoles and derivatives, and a route to analogs of the antitumor agent PLX-4032 is demonstrated. The utility of the HK substrates is further demonstrated through bioconjugation and subsequent ring closure and via Huisgen type [3+2] cycloaddition chemistry, allowing formation of peptide adducts which can be subsequently labeled with fluorine tags.

[Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source

The syntheses of alkaloids including indoles, indolines, tetrahydroquinolines, dihydroquinazolinones and quinazolinones have been accomplished in moderate to excellent yields via [Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation using aryl azides as nitrogen source.