98088-36-9Relevant academic research and scientific papers
Efficient total syntheses of pumiliotoxins A and B. Applications of iodide-promoted iminium ion-alkyne cyclizations in alkaloid construction
Lin, Nan-Horng,Overman, Larry E.,Rabinowitz, Michael H.,Robinson, Leslie A.,Sharp, Matthew J.,Zablocki, Jeffery
, p. 9062 - 9072 (1996)
A practical route for the total synthesis of pumiliotoxin A alkaloids is described. The central step is formation of the piperidine ring and establishment of the (Z)-alkylidene side chain by an iodide-promoted iminium ion-alkyne cyclization. The total syn
Enantioselective Total Synthesis of (+)-Pumiliotoxin A
Overman, Larry E.,Lin, Nan-Horng
, p. 3669 - 3670 (2007/10/02)
(+)-Pumiliotoxin A (2), the parent alkaloid of the cardiac-active pumiliotoxin A class, can be prepared in 13 steps and 5percent overall yield from (S)-(-)-2-methyl-1-penten-3-ol (4).This enantioselective total synthesis establishes, for the first time, t
