98090-60-9Relevant academic research and scientific papers
Intramolecular stereoselective protonation of aldehyde-derived enolates
Kena-diba, Anastasie,Noll, Claudia,Richter, Michael,Gieseler, Marc Timo,Kalesse, Markus
supporting information; experimental part, p. 8367 - 8369 (2010/12/25)
Picking sides: Asymmetric protonation of the titled compounds poses a most significant challenge and has been addressed by taking advantage of internal protonation and subsequent hemiacetal formation to avoid epimerization (see scheme). The substrates employed in these transformations can be easily accessed through a sequence of vinylogous aldol reactions with subsequent conjugate reductions.
Lewis Acid Promoted Electrophilic Aromatic Substitution Reaction of Nitrile Oxide: Increase of the Electrophilicity of Carbon Atom of Nitrile Oxide by Lewis Acid Complexation
Kim, Jae Nyoung,Ryu, Eung K.
, p. 3567 - 3570 (2007/10/02)
Nitrile oxides complexed with Lewis acid have their increased electrophilic character at the carbon atom and could be used as hydroxynitrilium ion equivalents toward aromatic compounds.
Anticonvulsant activity of some 4-methoxy- and 4-chlorobenzanilides
Clark,McMillian
, p. 220 - 222 (2007/10/02)
A series of mono-, di-, and trimethylated derivatives of 4-chloro- and 4-methoxybenzanilide was synthesized and evaluated for anticonvulsant activity. This series was prepared in the course of studies designed to examine the relationship between anticonvulsant effects and benzamide structure. The compounds were tested in mice against seizures induced by maximal electroshock (MES) and pentylenetetrazole (scMet), as well as with the rotorod assay for neurologic deficit. In mice dosed intraperitoneally, 4-methoxy-2, 6-dimethylbenzanilide (4) showed a median anticonvulsant potency (ED50) of 18.58 mg/kg in the MES test and a median toxicity (TD50) of 133.72 mg/kg in the rotorod toxicity assay, yielding a protective index (PI = TD50/ED50) of 7.2. In mice dosed orally with 4, the anti-MES ED50 was 27.40 mg/kg and the TD50 dose was determined to be 342.58 mg/kg, resulting in a protective index of 12.5.
