98137-96-3

Usage

Uses

1. Used in Chemical Synthesis:
1,3-Dibromo-2-iodo-5-nitrobenzene is used as an intermediate in the synthesis of various organic compounds. Its unique structure with multiple halogens and a nitro group allows for a range of chemical reactions, making it a valuable building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
2. Used in Material Science:
In the field of material science, 1,3-dibromo-2-iodo-5-nitrobenzene is used as a precursor for the development of new materials with specific properties. Its halogenated structure can contribute to the formation of novel polymers, dyes, and other materials with potential applications in various industries.
3. Used in Research and Development:
1,3-Dibromo-2-iodo-5-nitrobenzene is utilized in research and development settings to study the effects of halogenated benzene derivatives on biological systems. Its unique structure allows researchers to investigate the interactions of 1,3-DIBROMO-2-IODO-5-NITROBENZENE with biological molecules, potentially leading to the discovery of new therapeutic agents or understanding the mechanisms of action of existing compounds.
4. Used in Environmental Applications:
In environmental applications, 1,3-dibromo-2-iodo-5-nitrobenzene may be used as a tracer or a model compound to study the behavior of halogenated aromatic compounds in the environment. This can help in understanding the fate and transport of these compounds in the ecosystem, as well as their potential impact on human health and the environment.
5. Used in Analytical Chemistry:
1,3-Dibromo-2-iodo-5-nitrobenzene is employed as a reference compound in analytical chemistry for the development and validation of analytical methods. Its distinct chemical properties make it suitable for testing the accuracy and precision of various analytical techniques, such as chromatography, spectroscopy, and mass spectrometry.

InChI:InChI=1/C6H2Br2INO2/c7-4-1-3(10(11)12)2-5(8)6(4)9/h1-2H

Upstream product

• 827-94-1 2,6-dibromo-4-nitroaniline 
• 525584-72-9 2,6-dibromo-4-nitrophenyl trifluoromethanesulfonate 
• 99-28-5 2,6-dibromo-4-nitrophenol 
• 100-01-6 4-nitro-aniline 
• 401631-97-8 C₁₀H₁₂Br₂N₄O₂ 

Downstream Products

• 60962-93-8 1-(2,6-dibromo-4-nitro-phenoxy)-4-methoxy-benzene 
• 6311-60-0 3,5-dibromonitrobenzene 
• 854234-97-2 2,6,3'-tribromo-2'-iodo-4,5'-dinitro-biphenyl 
• 854235-08-8 2,6,2',6'-tetrabromo-4,4'-dinitro-biphenyl 
• 857751-53-2 2,6,2'',6''-tetrabromo-2'-iodo-4,5',4''-trinitro-m-terphenyl 
• 28818-54-4 3,5-dibromo-4-(4-methoxy-phenoxy)-aniline 
• 855264-88-9 3,5-dibromo-4-(4-methoxy-phenoxy)-benzaldehyde 
• 860594-97-4 3,5-dibromo-4-(4-methoxy-phenoxy)-benzonitrile 
• 258820-25-6 1,3-dibromo-2-(3-isopropyl-4-methoxyphenoxy)-5-nitrobenzene 
• 918946-07-3 6-(2,6-dibromo-4-nitrophenoxy)-2-methylquinoline 
• 169113-83-1 3,5-dibromo-4-(3-isopropyl-4-methoxyphenoxy)aniline 
• 355129-18-9 4-((3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl)amino)-4-oxobutanoic acid 
• 355129-22-5 4-(4-amino-2,6-dibromophenoxy)-2-isopropylphenol 
• 525584-73-0 4-(2,6-dibromo-4-nitrophenoxy)-2-isopropylphenol 

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Enantioposition-selective copper-catalyzed azide-alkyne cycloaddition for construction of chiral biaryl derivatives

A highly enantioposition-selective copper-catalyzed azide-alkyne cycloaddition (CuAAC) of dialkynes bearing prochiral biaryls has been developed for the construction of 1,2,3-triazoles bearing axially chiral biaryl groups in up to 76% yield and up to 99% ee.

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1-Aryl-3,3-dialkyltriazenes: A convenient synthesis from dry arenediazonium o-benzenedisulfonimides - A high yield break down to the starting dry salts and efficient conversions to aryl iodides, bromides and chlorides

This research comprises three parts. The first part regards the synthesis of 1-aryl-3,3-dialkyltriazenes 3 by reaction of dry arenediazonium o-benzenedisulfonimides 1, also coming from weakly basic aromatic amines with dimethylamine or diethylamine in aqueous solution at 0-5 °C. Yields were usually greater than 90% and there was the possibility of recovering the o-benzenedisulfonimide (5), which could be reused to prepare the salts 1. In the second part it was demonstrated that there is the possibility of reconverting the triazenes 3 into the starting stable dry salts 1 by using 5 as acid. The reactions were carried out in glacial acetic acid at 50-55 °C and normally afforded salts 1 in yields of around 90-99%. The third part concerns the setting up of two procedures for the conversion of 3 to aryl iodides 9, bromides 10 and chlorides 11. Procedure A used the corresponding aqueous hydrogen halides in acetonitrile at r.t. or 60 °C, sometimes in the presence of aqueous HBF4, sometimes Cu powder (25 examples, yields 65%-88%). Procedure B usually used anhydrous methanesulfonic acid and tetraalkylammonium halides in anhydrous acetonitrile at temperatures varying from r.t. to 80 °C, sometimes in the presence of Cu (16 examples, yields 65-88%).