99-28-5

Basic information

• Product Name: 2,6-Dibromo-4-nitrophenol
• Synonyms: Dibromo-4-nitrophenol, 2,6-;2,6-DibroMo-4-nitrop;2,6-dibromo-4-nitro-pheno;4-Nitro-2,6-dibromophenol;Phenol, 2,6-dibromo-4-nitro-;2,6-DIBROMO-4-NITROPHENOL;2,6-Dibromo-4-mitrophenol;2,6-Dibromo-4-nitrophenol, 99+%
• CAS NO: 99-28-5
• Molecular Formula: C₆H₃Br₂NO₃
• Molecular Weight: 296.9
• EINECS: 202-744-3
• Product Categories: Nitro Compounds;Phenols;Organic Building Blocks;Oxygen Compounds;Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Bromine Compounds
• Mol File: 99-28-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 145 °C (dec.)(lit.)
• Boiling Point: 297.8 °C at 760 mmHg
• Flash Point: 133.9 °C
• Appearance: yellow columnar crystals
• Density: 2.3436 (rough estimate)
• Vapor Pressure: 0.000744mmHg at 25°C
• Refractive Index: 1.6220 (estimate)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.67±0.44(Predicted)
• BRN: 1245050
• CAS DataBase Reference: 2,6-Dibromo-4-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dibromo-4-nitrophenol(99-28-5)
• EPA Substance Registry System: 2,6-Dibromo-4-nitrophenol(99-28-5)

Safety Data

• Hazard Codes: Xn,C
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-37
• WGK Germany: 3
• RTECS: SK8025000
• TSCA: Yes
• Hazardous Substances Data: 99-28-5(Hazardous Substances Data)

Usage

Chemical Properties

yellow crystalline powder

Purification Methods

Crystallise the phenol from aqueous EtOH, 50% aqueous AcOH (m 144-145o, dec varies with rate of heating). Dry it in an oven at 40-60o or in vacuo over NaOH. [Hartman & Dickey Org Synth Coll Vol II 173 1943, Beilstein 6 H 246, 6 I 123, 6 II 234, 6 III 849, 6 IV 1366.]

InChI:InChI=1/C6H3Br2NO3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H/p-1

Upstream product

• 96-97-9 5-nitrosalicylic acid 
• 64-19-7 acetic acid 
• 118-79-6 2,4,6-tribromophenol 
• 100-02-7 4-nitro-phenol 
• 7726-95-6 bromine 
• 15969-09-2 2,4-dibromo-6-nitrophenol 
• 7732-18-5 water 
• 608-33-3 2,6-dibromophenol 
• 7697-37-2 nitric acid 
• 616-59-1 2-hydroxyl-5-nitrobenzenesulfonic acid 
• 64-17-5 ethanol 
• 637-62-7 p-benzoquinone oxime 
• 4232-99-9 3,5-dibromo-4-hydroxy-benzenesulfonic acid 
• 92874-42-5 2,6,2',6'-tetrabromo-4,4'-sec-butylidene-di-phenol 

Downstream Products

• 488-48-2 tetrabromobenzoquinone 
• 537-45-1 2,6-Dibrom-1,4-benzochinon-4-chlorimin 
• 609-21-2 2,6-dibromo-4-aminophenol 
• 32279-12-2 (2.6-Dibrom-4-nitro-phenyl)-acetat 
• 29276-38-8 2,6-dibromo-4-nitrophenol*triethylamine 
• 867288-05-9 1,3-Dibromo-2-(2-chloro-6-fluoro-benzyloxy)-5-nitro-benzene 
• 31106-74-8 1,3-dibromo-2-methoxy-5-nitrobenzene 
• 38676-25-4 4-Diazo-2,6-dibromo-2,5-cyclohexadienone 
• 355129-18-9 4-((3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl)amino)-4-oxobutanoic acid 
• 355129-22-5 4-(4-amino-2,6-dibromophenoxy)-2-isopropylphenol 
• 525584-73-0 4-(2,6-dibromo-4-nitrophenoxy)-2-isopropylphenol 
• 258820-25-6 1,3-dibromo-2-(3-isopropyl-4-methoxyphenoxy)-5-nitrobenzene 
• 98137-96-3 1,3-dibromo-2-iodo-5-nitrobenzene 
• 525584-72-9 2,6-dibromo-4-nitrophenyl trifluoromethanesulfonate 

Relevant articles and documents

Quinazoline derivative and preparation method and application thereof

The invention discloses a novel compound 4-(3 '-R substituted-5'-R substituted-4 '-hydroxyanilino) quinazoline derivative and a preparation method and application thereof. The structural formulas of the compound are shown as formulas I and II. The compound has good activity of preventing and treating chicken coccidiosis and can be used as a therapeutic agent for preventing and treating chicken coccidiosis in the field of preparation of medicines for preventing and treating chicken coccidiosis.

A quick, mild and efficient bromination using a CFBSA/KBr system

Bromination is a fundamental transformation in organic chemistry and brominated compounds as building blocks are of paramount importance in organic synthesis. In our study, we have developed an efficient method of bromination by using a CFBSA/KBr system at room temperature in a short reaction time. Notably, this approach has been proven to be applicable to a range of substrates including 1,3-diketones and β-keto esters, phenols, aromatic amines and heteroarenes with good to excellent yields.

A simple protocol for the visual discrimination of natural cyclodextrins in aqueous solution using perichromic probes

(Graph Presented) Three synthesized compounds, 4-(4-nitrostyryl)phenol, 2,6-dibromo-4-(2,4-dinitrobenzylideneamino) phenol and 2,6-dichloro-4-(2,4-dinitrobenzylideneamino)phenol, were deprotonated to generate the perichromic dyes 2b, 3b and 4b, respectively. These dyes were used as probes to investigate the micropolarity of natural cyclodextrins (CyDs) and it was observed that they interact differently with the CyDs according to the molecular structure of the dye and the diameter of the CyD. The solvatochromic bands of the dyes that interacted with the CyDs were bathochromically shifted, suggesting that the probes were transferred to the hydrophobic interior of the CyD in aqueous solution. Dyes 2b and 4b were found to be very selective for α-CyD and γ-CyD, respectively, while β- and γ-CyD changed the color of the solution of compound 3b. These dyes were then successfully used in a simple assay that allows the naked-eye discrimination of natural CyDs in aqueous solution, without the need for expensive techniques.