169113-83-1Relevant academic research and scientific papers
Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa
Kitamura, Seiya,Hvorecny, Kelli L.,Niu, Jun,Hammock, Bruce D.,Madden, Dean R.,Morisseau, Christophe
, p. 4790 - 4799 (2016/06/13)
The virulence factor cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) is secreted by Pseudomonas aeruginosa and is the founding member of a distinct class of epoxide hydrolases (EHs) that triggers the catalysis-dependent
Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β
Garcia Collazo, Ana-Maria,Koehler, Konrad F.,Garg, Neeraj,Faernegardh, Mathias,Husman, Bolette,Ye, Liu,Ljunggren, Jan,Mellstroem, Karin,Sandberg, Johnny,Grynfarb, Marlena,Ahola, Harri,Malm, Johan
, p. 1240 - 1244 (2007/10/03)
Based on the examination of the crystal structure of rat TRβ complexed with 3,5,3′-triiodo-l-thyronine (2) a novel TRβ-selective indole derivative 6b was prepared and tested in vitro. This compound was found to be 14 times selective for TRβ over TRα in bi
Synthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to L-Thyronine
Yokoyama, Naokata,Walker, Gordon N.,Main, Alan J.,Stanton, James L.,Morrissey, Michael M.,et al.
, p. 695 - 707 (2007/10/02)
Aryloxamic acids 7 and 23, (arylamino)acetic acids 29, arylpropionic acids 33, arylthioacetic acids 37, and (aryloxy)acetic acid 41 related to L-triiodothyronine (L-T3) were prepared and tested in vitro for binding to the rat liver nuclear L-T
