98183-15-4

Basic information

• Product Name: 2-[(1-Acetyl-2-oxopropyl)thio]-N-cyclohexyl-1H-benzimidazole-1-carboxamide
• Synonyms: 2-[(1-Acetyl-2-oxopropyl)thio]-N-cyclohexyl-1H-benzimidazole-1-carboxamide;5'-Dimethoxytrityl-N-isobutyryl-2'-deoxyGuanosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite;DMT-dG-CEPhosphoramidite;2'-DEOXYGUANOSINE PHOSPHORAMIDITE
• CAS NO: 98183-15-4
• Molecular Formula: C19H23N3O3S
• Molecular Weight: 373.47
• Mol File: 98183-15-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.34
• Refractive Index: 1.66
• CAS DataBase Reference: 2-[(1-Acetyl-2-oxopropyl)thio]-N-cyclohexyl-1H-benzimidazole-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(1-Acetyl-2-oxopropyl)thio]-N-cyclohexyl-1H-benzimidazole-1-carboxamide(98183-15-4)
• EPA Substance Registry System: 2-[(1-Acetyl-2-oxopropyl)thio]-N-cyclohexyl-1H-benzimidazole-1-carboxamide(98183-15-4)

Safety Data

• Hazardous Substances Data: 98183-15-4(Hazardous Substances Data)

Usage

General Description

2-[(1-Acetyl-2-oxopropyl)thio]-N-cyclohexyl-1H-benzimidazole-1-carboxamide is a chemical compound with the molecular formula C20H23N3O3S. It is a derivative of benzimidazole and contains a cyclohexyl and acetyl group. 2-[(1-Acetyl-2-oxopropyl)thio]-N-cyclohexyl-1H-benzimidazole-1-carboxamide has shown potential as a therapeutic agent due to its diverse biological activities, including antiproliferative, antitumor, and anti-inflammatory properties. Its unique structure makes it a promising candidate for drug development, particularly in the treatment of cancer and inflammatory diseases. Further research is needed to fully understand its potential benefits and mechanisms of action.

InChI:InChI=1/C19H23N3O3S/c1-12(23)17(13(2)24)26-19-21-15-10-6-7-11-16(15)22(19)18(25)20-14-8-4-3-5-9-14/h6-7,10-11,14,17H,3-5,8-9H2,1-2H3,(H,20,25)

Upstream product

• 538-75-0 dicyclohexyl-carbodiimide 
• 87504-17-4 2-cyclohexylbenzimidazo<1,2-d><1,2,4>thiadiazol-3(2H)-one 
• 123-54-6 acetylacetone 

Relevant articles and documents

Exchange, Elimination, and Ring Opening Reactions of 2,3-Dihydrobenzimidazothiadiazoles and 3H-Benzimidazodithiazoles

The reactions of benzimidazothiadiazol-3(2H)-ones (1) with isocyanates, isothiocyanates, carbon disulphide, aryl cyanates, acetylenedicarboxylates, and enamines, with exchange of the isocyanate component of (1), to give the corresponding condensed benzimidazole derivatives (1)-(6) are described.Under more severe conditions the 1-benzothiazol-2-yl-1,3-dihydrobenzimidazole-2-thiones (7) were obtained from aromatic isothiocyanates.Thermolysis of the thiadiazoles (1) led to the triazine derivative (12) with elimination of isocyanate and sulphur, and in the presence of phenols to the 2-aryloxybenzimidazoles (13).With amines and CH-acidic compounds, the S,N bond in compound (1) was cleaved to give benzimidazol-2-ylsulphenamides (14), and the ω-substituted methylthiobenzimidazoles (17) and (18).With cyanide ion, insertion into the S,N bond of compound (1) to furnish the thiadiazine (22) took place.The dithiazoles (2) were fragmented by amines to give 1,3-dihydrobenzimidazole-2-thione and guanidine with loss of sulphur; reaction with cyanide ion then gave the dibenzimidazothiadiazine (25).