98198-62-0

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Pyrimidine, 4-(chloromethyl)-6-methyl(6CI) is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure allows it to be a key component in the development of new drugs and pesticides, contributing to the advancement of these industries.
Used in Materials Science:
In the field of materials science, Pyrimidine, 4-(chloromethyl)-6-methyl(6CI) has potential applications in the development of organic semiconductors and optoelectronic devices. Its specific molecular structure makes it a promising candidate for improving the performance of these devices and expanding their applications.
Used in the Synthesis of Bioactive Compounds:
Pyrimidine, 4-(chloromethyl)-6-methyl(6CI) may have some biological activity and could be used as an intermediate in the synthesis of bioactive compounds. Its presence in the molecular structure of these compounds could enhance their therapeutic effects and contribute to the discovery of new bioactive substances with potential applications in medicine and healthcare.

Upstream product

• 14161-42-3 4,6-dimethylpyrimidine 1-oxide 
• 98-59-9 p-toluenesulfonyl chloride 
• 1558-17-4 4,6-dimethylpyrimidine 
• 74502-82-2 (6-methylpyrimidin-4-yl)methanol 
• 148149-29-5 ethyl 6-methylpyrimidine-4-carboxylate 
• 62501-45-5 4,6-dimethylpyrimidine-2(1H)-thione hydrochloride 

Relevant academic research and scientific papers

Reaction of β-alkoxyvinyl α-ketoesters with acyclic NCN binucleophiles – Scalable approach to novel functionalized pyrimidines

Two protocols for synthesis of series of low-molecular-weight di- and tri-substituted pyrimidines bearing a functional group at the 4th position, which rely on a base-mediated condensation of amidines or guanidines with β-alkoxyvinyl α-keto esters, have been developed. This approach allowed for multigram preparation of novel pyrimidine-4-carboxylates in 21–90% yield. The synthetic utility of these compounds was demonstrated by some standard functional group transformations providing promising building blocks for organic synthesis and drug discovery.

Improved Halogenation of Methyl Aromatics and Methyl Heteroaromatics: Unexpected Reactivity of Tetrahalogeno-diphenylglycolurils

1,3,4,6-Tetrachloro (TCDGU) and 1,3,4,6-tetrabromo-3α,6α-diphenylglycolurils smooth halogen oxidizers have been exploited in a new direction as reagents for free radical substitution toward some N-halosuccinimide nonreactive bis-heterocycles. An unexpected selectivity and reactivity were observed with methyl benzenes, methyl heterocycles, and methyl-bis-heterocycles of interest. A chemometric study has been performed to optimize five independent factors of the chlorination reaction with TCDGU. The predictive model was established either for the halogenation conversion and the ratio of monochlorination.

STUDIES ON PYRIMIDINE DERIVATIVES. XXXI. SYNTHESIS OF CHLOROMETHYLPYRIMIDINES BY REACTION OF MONOMETHYL-PYRIMIDINE N-OXIDES WITH PHOSPHORYL CHLORIDE

The reaction of 2- and 6-methylpyrimidine 1-oxides with phosphoryl chloride underwent the selective side-chain chlorination to give 2- and 6-chloromethylpyrimidines as sole products.No by-products such as 2-chloro- and 4-chloropyrimidines were obtained ev

PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.

PHARMACOLOGICALLY ACTIVE THIOUREA AND UREA COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.