98229-10-8Relevant academic research and scientific papers
On the Use of Carboxamidomethyl Esters in the Protease-Catalyzed Peptide Synthesis
Kuhl, Peter,Zacharias, Ute,Burckhardt, Helmut,Jakubke, Hans-Dieter
, p. 1195 - 1204 (2007/10/02)
Carboxyamidomethyl esters (CAM esters) of Z-and Boc-protected alanine and phenylalanine were prepared in order to investigate their usefulness as substrates for α-chymotrypsin- and papain-catalyzed hydrolysis and peptide synthesis reactions.The easy removal of the CAM-C-protecting group under mild conditions and dependent on the enzyme specificity was demonstrated.Examples are given for the protease-catalyzed synthesis of various peptide derivatives using CAM esters as C- and N-components in aqueous-organic media.Comparatively short reaction times were observed. - Key words: Carboxyamidomethyl ester as C-protecting group; Enzymatic deprotection; Peptide synthesis; α-Chymotrypsin- and Papain-catalyzed peptide bond formation
ON THE USE OF CARBOXAMIDOMETHYL ESTERS ( CAM ESTERS ) IN THE SYNTHESIS OF MODEL PEPTIDES. SCOPE AND LIMITATIONS
Martinez, Jean,Laur, Janine,Castro, Bertrand
, p. 739 - 744 (2007/10/02)
The usefulness of carboxamidomethyl esters ( CAM esters ) as a carboxyl protecting group for peptide synthesis was demonstrated.The synthesis of the chemotactic peptide For-Met-Leu-Phe-OH as well as the synthesis of Met-enkephalin using CAM ester as carbo
