98259-91-7

Upstream product

• 67-56-1 methanol 
• 91366-06-2 (1R,2S- and 1S,2R)-2-methyl-1-aminocyclopropane-1-carboxylic acid 
• 138571-79-6 3-tert-Butoxycarbonylamino-5-methyl-4,5-dihydro-3H-pyrazole-3-carboxylic acid methyl ester 
• 120238-58-6 Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate 
• 120238-59-7 Methyl (Z)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate 
• 138571-85-4 N-(tert-butyloxycarbonyl)-1-amino-(E)-2-methylcyclopropanecarboxylic acid methyl ester 
• 138571-81-0 (3R,4R)-3-tert-Butoxycarbonylamino-4-methyl-4,5-dihydro-3H-pyrazole-3-carboxylic acid methyl ester 
• 63096-22-0 C₁₀H₁₈ClNO₄ 
• 58561-08-3 (S)-methyl 2-(((tert-butoxy)carbonyl)amino)butanoate 
• 60538-19-4 N-(tert-butoxycarbonyl)-l-threonine methyl ester 
• 63658-16-2 (Z)-methyl 2-((tertbutoxycarbonyl)amino)but-2-enoate 
• 138571-85-4 N-(tert-butyloxycarbonyl)-1-amino-(Z)-2-methylcyclopropanecarboxylic acid methyl ester 

Downstream Products

• 98302-68-2 (1R,2S)-1-((R)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-methyl-cyclopropanecarboxylic acid methyl ester 
• 98302-69-3 (1S,2R)-1-((R)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-methyl-cyclopropanecarboxylic acid methyl ester 
• 98259-92-8 (1R,2S)-1-((S)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-methyl-cyclopropanecarboxylic acid methyl ester 
• 98392-11-1 (1S,2R)-1-((S)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-methyl-cyclopropanecarboxylic acid methyl ester 

Relevant academic research and scientific papers

1-Aminocyclopropane-1-carboxylic acid derivatives: A new, general synthesis and NMDA receptor complex binding affinity study

A new synthesis of 1-aminocyclopropane-1-carboxylic acid and of its (E)- and (Z)-2-substituted analogues (R = CH3;i-Pr;C6H5) has been performed by means of the 'diazo-addition' method, starting from N-(diphenylmethylene)-2,3-dehydro-1-amino-1-carboxylate precursors. The (E)- and (Z)-2-phenyl and the (Z)-2-methylcyclopropaneamino acids have been obtained with high diastereospecificity. All the cyclopropaneamino acids prepared were tested for their affinity for some glutamate receptors and resulted inactive, wich the exception of compounds (E)-1b and (Z)-1c which showed a shallow displacement of [H]-glycine binding.

Synthesis and Taste Properties of L-Aspartyl-Methylated 1-Aminocyclopropanecarboxylic Acid Methyl Esters

Several isomers of L-aspartyl-1-aminocyclopropanecarboxylic acid methyl ester with methyl group substitutions on the cyclopropane ring were synthesized.Conformational analyses were carried out on these molecules using 1H NMR and molecular modeling studies.Their taste properties are explained on the basis of our previously reported topochemical model for taste response.

THE RESOLUTION OF RACEMIC 2-ALKYL-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACIDS

Practical procedures for the resolution of racemic modification of (1R, 2S)- and (1S, 2R)-1-amino-2-ethylcyclopropane-1-carboxylic acid 1a,b,(1R, 2S)- and (1S, 2R)-1-amino-2-methylcyclopropane-1-carboxylic acid 2a,b, and (1R, 2R)- and (1S, 2S)-1-amino-2-methylcyclopropane-1-carboxylic acid 3a,b are described; the structures as 1a,2a, and 3a were confirmed by X-ray crystallographic methods.