98265-88-4

Upstream product

• 51673-84-8 dimethoxyacetaldehyde 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 
• 22483-09-6 2,2-dimethoxyethylamine 
• 5437-45-6 Benzyl bromoacetate 

Downstream Products

• 406954-88-9 N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide 
• 60744-45-8 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid 
• 406954-87-8 phenylmethyl 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetate 

Relevant academic research and scientific papers

BETA-STRAND MIMETICS AND METHOD RELATING THERETO

Conformationally constrained compounds which mimic the secondary structure of ?-strand regions of biologically active peptides and proteins are disclosed. Such ?-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the ?-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.

Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals

Bicyclization of peptide acetals via nucleophilic attack of a phenyl group on an endocyclic acyliminium ion 4 was explored as a route to novel amino acid derived heterocycles and peptidomimetic scaffolds. In the presence of protic acid, bridged structures such as 6 are formed readily from phenylalanine derivatives, but the fused-ring analogues 5 could not be obtained in good yield. In contrast, radical cyclization of the bromophenyl dihydropyrazinone 7 provides an effective alternative for the synthesis of 5 (n = 0, 1, 2). Additional versatility in this process was demonstrated by efficient synthesis of a different fused ring system, represented by the antihelmintic praziquantel, 8.

3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones

Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and a 1-substituent of the formula STR1 (or a salt or ester thereof).