98323-83-2 Usage
Uses
Carmoxirole is a selective, peripherally acting D2-like agonist.
Definition
ChEBI: An indolecarboxylic acid that is indole-5-carboxylic acid bearing an additional 4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl substituent at position 3. Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradren
lin release and sympathetic activation. Displays antihypertensive properties in vivo.
Biological Activity
Selective, peripherally acting dopamine D 2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 98323-83-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,3,2 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 98323-83:
(7*9)+(6*8)+(5*3)+(4*2)+(3*3)+(2*8)+(1*3)=162
162 % 10 = 2
So 98323-83-2 is a valid CAS Registry Number.
InChI:InChI=1/C24H26N2O2/c27-24(28)20-9-10-23-22(16-20)21(17-25-23)8-4-5-13-26-14-11-19(12-15-26)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,25H,4-5,8,12-15H2,(H,27,28)
98323-83-2Relevant academic research and scientific papers
A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5- carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone
Heinrich, Timo,Boettcher, Henning
, p. 2681 - 2684 (2007/10/03)
A major metabolite of the potential antidepressant vilazodone formed in rat, dog, monkey and human liver microsomes is the 5-cyano-6-hydroxy-1H-indole derivative. For the construction of the salicyl-like substituted indole we adapted a synthesis of carmox
Synthesis of 3--5-indolecarboxylic Acid, an Antihypertensive Agent with a Novel Mode of Action
Boettcher, Henning,Gericke, Rolf
, p. 749 - 752 (2007/10/02)
The pharmacologically active title compound 1c is prepared in a straightforward six-stage synthesis.The intermediate 4 is obtained by Leimgruber-Batcho indole synthesis.The 3-alkyl side chain is introduced by Friedel-Crafts acylation with 4-chlorobutyryl
