98381-01-2Relevant academic research and scientific papers
Synthesis of Highly Substituted 1,2-Diazetidin-3-ones, Small-Ring Scaffolds for Drug Discovery
Santos, Marilia S.,Nortcliffe, Andrew,Lewis, William,Bradshaw, Tracey D.,Moody, Christopher J.
, p. 8325 - 8330 (2018)
1,2-Diazetidin-3-ones are readily accessible, small ring scaffolds that upon functionalization have the potential to produce diverse 3-dimensional structures for drug discovery. Thus, treatment of diazo hydrazides, obtained from simple hydrazides and malonyl half ester derivatives, followed by diazo transfer, with catalytic amounts of rhodium(II) acetate dimer results in intramolecular carbenoid N?H insertion to give 1,2-diazetidin-3-ones. Although subsequent functionalization reactions could be hampered by the lability of the 4-membered ring, a wide range of new derivatives was available by deprotection at N-1, and subsequent amide or urea formation. The structures of four four-membered rings was confirmed by X-ray crystallography; the compounds showed modest growth inhibitory activity in mammary carcinoma cells.
Rhodium Carbenoid Mediated Cyclisations. Synthesis of 1,2-Diazetidinones (Aza-β-lactams).
Lawton, Geoffrey,Moody, Christopher J.,Pearson, Christopher J.
, p. 899 - 902 (2007/10/02)
Decomposition of the diazo hydrazides (1b-h) in boiling benzene in the presence of a catalytic amount of rhodium(II) acetate gives the corresponding 1,2-diazetidinones (2) in good yield.The aza-β-lactams (2) exhibit the expected high frequency carbonyl st
SYNTHESIS OF AZA-β-LACTAMS BY RHODIUM CARBENOID MEDIATED CYCLISATION
Moody, Christopher J.,Pearson, Christopher J.,Lawton, Geoffrey
, p. 3171 - 3172 (2007/10/02)
Treatment of the diazo-compounds (3), obtained in two steps from readily available hydrazine derivatives (1), with a catalytic amount of rhodium (II) acetate in benzene gives the aza-β-lactams (4) in high yield.
