98383-56-3

Basic information

• Product Name: 2,2-bis(4-fluorophenyl)ethylamine
• Synonyms: 2,2-bis(4-fluorophenyl)ethylamine;2,2-Bis(4-fluorophenyl)ethanamine;2,2-bis(4-fluorophenyl)ethan-1-aMine
• CAS NO: 98383-56-3
• Molecular Formula: C₁₄H₁₃F₂N
• Molecular Weight: 233.2565264
• Mol File: 98383-56-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 317.6°C at 760 mmHg
• Flash Point: 189.1°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0.000381mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 2,2-bis(4-fluorophenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-bis(4-fluorophenyl)ethylamine(98383-56-3)
• EPA Substance Registry System: 2,2-bis(4-fluorophenyl)ethylamine(98383-56-3)

Safety Data

• Hazardous Substances Data: 98383-56-3(Hazardous Substances Data)

Usage

Class

Substituted amphetamines

Psychoactive effects

Stimulant effects mimicking amphetamine and MDMA

Legal status

Illegal in many countries due to potential harm and abuse

Recreational use

Sold as a recreational drug

Adverse effects

Non-fatal and fatal overdose, cardiovascular and central nervous system issues

Potency

Potent serotonergic and dopaminergic agent

InChI:InChI=1/C14H13F2N/c15-12-5-1-10(2-6-12)14(9-17)11-3-7-13(16)8-4-11/h1-8,14H,9,17H2

Upstream product

• 27064-94-4 4,4'-difluorobenzhydryl chloride 
• 462-06-6 fluorobenzene 
• 645-36-3 2,2-diethoxy-ethanamine 
• 37742-99-7 4-fluoro-α-(4-fluorophenyl)benzeneacetonitrile 
• 6175-14-0 1,1-bis-(4-fluorophenyl)ethene 

Downstream Products

• 140945-01-3 S 9788 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

New Triazine Derivatives as Potent Modulators of Multidrug Resistance

A series of 70 triazine derivatives have been synthesized and tested for their capacity to modulate multidrug resistance (MDR) in DC-3F/AD and KB-A1 tumor cells in vitro, in comparison with verapamil (VRP), a calcium channel antagonist currently used in therapy as an antihypertensive drug, which also shows MDR modulating activity.Among the 12 selected compounds, 16 (S9788) showed high MDR reversing properties in vitro (300- and 6-fold VRP at 5μM in DC-3F/AD and KB-A1 cells, respectively) and induced a strong accumulation of adriamycin.The relationship between the increase of ADR accumulation and the fold reversal induced by these compounds and their lack of effects on the sensitive DC-3F cells suggest that they act mainly by inhibiting the P-glycoprotein (Pgp) catalyzed efflux of cytotoxic agents, as already described for a majority of MDR modulators.In vivo, in association with the antitumor drug vincristine (0.25 mg/kg), 16 (100 mg/kg) increased the T/C by 39percent in mice bearing the resistant tumor cell line P388/VCR.According to these interesting properties, 16 was selected for a clinical development because it is more bioavailable than 34, even though it was less active.