98418-47-4 Usage
Antihypertensives
At present, it is a selective β1 receptor blocker which is widely used for high blood pressure, coronary heart disease, chronic heart failure and cardiac arrhythmia treatment,Metroprolol succinate is a conventional tablet of metoprolol , its elimination half-life is shorter than others, about 3 to 4 hours, so the plasma drug concentration fluctuation is great, and2 to 4 times daily medication is necessary. To overcome these disadvantages, AstraZeneca's recently introduced metoprolol succinate sustained-release tablet is a new depot metoprolol , once-daily medication can guarantee 24 hours of constant metoprolol plasma concentration and β1-receptor blocking effect .On clinical pharmacology and therapeutics ,it has many advantages. Clinically it is used for the treatment of hypertension, angina pectoris, chronic heart failure with left ventricular systolic dysfunction and stable symptoms.
Oral, once a day, take preferably in the morning, it can be broken apart and taken, but you can not chew or crush,at least half a cup of liquid should be taken for delivery . At the same time food intake does not affect their bioavailability. Dosage should be individualized to avoid bradycardia. The following is an effective medication guide: high blood pressure: 47.5~95mg, once daily. Taking 95mg of metoprolol succinate sustained-release tablets may be ineffective in patients ,combine them with other anti-hypertensive drugs, preferably diuretics and dihydropyridine calcium antagonists, or increase the dose. Angina: 95~190mg, once daily.Combine them with nitrates or increase the dose if it is needed.
The above information is edited by the lookchem of Tian Ye.
Uses
Different sources of media describe the Uses of 98418-47-4 differently. You can refer to the following data:
1. High blood pressure medication.
2. Metoprolol Succinate is used in the treatment of patients suffering from chronic heart failure, as well as to treat blood pressure from mild hypertension. β-adrenoceptor antagonist or β-blocker.
3. Anti - hypertensives
Brand name
Toprol (AstraZeneca).
Check Digit Verification of cas no
The CAS Registry Mumber 98418-47-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,4,1 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 98418-47:
(7*9)+(6*8)+(5*4)+(4*1)+(3*8)+(2*4)+(1*7)=174
174 % 10 = 4
So 98418-47-4 is a valid CAS Registry Number.
InChI:InChI=1/2C15H25NO3.C4H6O4/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
98418-47-4Relevant articles and documents
Method for continuously synthesizing metoprolol and salts thereof
-
Paragraph 0032-0047, (2021/04/14)
The invention discloses a method for continuously synthesizing metoram, which comprises the following steps: (1) carrying out vacuum rectification on a 1-(2, 3-epoxypropoxy)-4-(2-methoxyethyl)benzene raw material to obtain a pure product with the purity of more than 99%, and preparing the pure product into an ethanol solution; (2) uniformly mixing the ethanol solution obtained in the step (1) with isopropylamine, feeding the mixture into a pipeline reactor, and reacting to obtain a metoprolol reaction solution; and (3) depressurizing the reaction liquid, and recovering isopropylamine in a rectifying tower, wherein the tower bottom liquid contains high-purity metoprolol. The purity of the raw materials reaches 99% or above through the rectification step, and colored impurities are also removed; when metoprolol is synthesized, a rapid reaction method of large excess of isopropylamine in the pipeline reactor is adopted, so that secondary condensation side reactions are obviously reduced, and the purity of metoprolol reaches 98% or above; and after metoprolol is salified with succinic acid, a crude drug finished product with the purity larger than 99.5% can be obtained through crystallization. The method is high in yield, low in cost and easy to operate, and is an environment-friendly process route capable of realizing industrial production.
Method for preparing metoprolol salt
-
Paragraph 0054; 0055, (2017/05/12)
The invention relates to a method for preparing a metoprolol salt which is simple to operate, high in yield, good in quality, low in cost and good in environmental-friendliness. According to the method provided by the invention, an acetone/water mixed solvent system is adopted, and an adverse dropping mode, that is, a mode that metoprolol is dropped into an organic acid solution, is adopted, so that the organic acid can be sufficiently dissolved, and a reaction can be sufficiently implemented, the reaction time can be greatly shortened, and the reaction conversion rate and the yield can be increased. The operation procedures are simplified, the time is shortened, the cost is lowered, and moreover, the quality of a product is greatly improved.
SYNTHESIS AND PREPARATIONS OF METOPROLOL AND ITS SALTS
-
Page/Page column 4, (2009/10/06)
The invention relates to an improved process for preparing metoprolol and its salts.
