98421-25-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
ETHYL QUINOLINE-5-CARBOXYLATE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its chemical structure makes it a valuable component in the development of new drugs and agricultural products, contributing to the advancement of these industries.
Used in Antibacterial and Antifungal Applications:
ETHYL QUINOLINE-5-CARBOXYLATE is used as an active ingredient for its potential antibacterial and antifungal properties. Its ability to combat microbial infections makes it a candidate for use in treatments and preventive measures against bacterial and fungal diseases.
Used in Neurodegenerative Disease Research and Treatment:
ETHYL QUINOLINE-5-CARBOXYLATE is used as a compound of interest in the field of medicinal chemistry for its potential role in the treatment and prevention of neurodegenerative diseases such as Alzheimer's and Parkinson's. Its investigation in this area highlights the possibility of developing new therapeutic approaches to combat these debilitating conditions.

Upstream product

• 7250-53-5 quinoline-5-carboxylic acid 
• 64-17-5 ethanol 
• 60-29-7 diethyl ether 
• 99-05-8 meta-aminobenzoic acid 

Downstream Products

• 16178-42-0 quinolin-5-ylmethanol 
• 96541-83-2 quinoline-5-carbohydrazide 
• 858784-68-6 N-(quinoline-5-carbonyl)-N'-(toluene-4-sulfonyl)-hydrazine 
• 98421-29-5 5-(2-benzamidoethyl)quinoline 
• 98421-32-0 5-(2-benzamidoethyl)carbostyril 
• 98421-31-9 5-(2-benzamidoethyl)quinoline N-oxide 
• 98421-28-4 5-(2-aminoethyl)quinoline 

Relevant academic research and scientific papers

Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: Synthesis, structure-activity relationship, and action mechanism studies

Bis-8-hydroxyquinoline substituted benzylamines have been synthesized and screened for their antitumor activity on KB3 cell line model. Synthesis of this series of new analogues was accomplished using a one pot specific methodology which allows the synthesis of both bis- and mono-8-hydroxyquinoline substituted benzylamines. Among the synthesized compounds two compounds (4a and 5a), respectively, named JLK 1472 and JLK 1486, were particularly potent on KB3 cell line. Their CC50 values being, respectively, 2.6 and 1.3 nM. Screened on a panel of cell lines showing various phenotype alterations, both compounds were found inactive on some cell lines such as PC3 (prostate cell line) and SF268 (neuroblastoma cell line) while highly active on other different cell lines. Mechanistic studies reveal that these two analogues did not affect tubulin and microtubules neither they exert a proteasomal inhibition effect. In contrast 4a and 5a activate specifically caspase 3/7 and not caspase 8 and 9, suggesting that their biological target should be located upstream from caspase 3/7. Moreover their cytotoxic effect is potentiated by the pro-apoptotic effects of TRAIL.

Dopamine Receptor Agonist Activity of Some 5-(2-Aminoethyl)carbostyril Derivatives

The potency of β-adrenoreceptor agonists, e.g.,isoproterenol, is strikingly increased by substitution of the meta catecholic hydroxyl group with the NH group of a carbostyril system.To explore the possibility that comparable potency enhacement might occur