7250-53-5

Usage

Uses

Used in Organic Synthesis:
Quinoline-5-carboxylic acid is used as a key intermediate for the synthesis of various organic compounds. Its unique structure and reactivity make it a versatile building block in the creation of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, quinoline-5-carboxylic acid is utilized as a starting material for the development of new drugs. Its structural properties allow for the design of molecules with specific biological activities, targeting a range of therapeutic areas.
Used in Agrochemicals:
Quinoline-5-carboxylic acid is employed as a raw material in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the creation of compounds that can effectively control pests and weeds in agricultural settings.
Used in Dyestuff Industry:
In the dyestuff industry, quinoline-5-carboxylic acid is used as a precursor for the synthesis of various dyes and pigments. Its ability to form colored compounds makes it a valuable component in the development of new colorants for a wide range of applications.

InChI:InChI=1/C10H7NO2/c12-10(13)8-3-1-5-9-7(8)4-2-6-11-9/h1-6H,(H,12,13)/p-1

Upstream product

• 7661-55-4 5-methylquinoline 
• 99-05-8 meta-aminobenzoic acid 
• 56-81-5 glycerol 
• 151-50-8 potassium cyanide 
• 5434-20-8 3-aminophthalic acid 
• 16675-62-0 methyl quinoline-5-carboxylate 

Downstream Products

• 98421-25-1 quinoline-5-carboxylic acid ethyl ester 
• 1344046-12-3 3-bromoquinoline-5-carboxylic acid 
• 899431-51-7 N-benzylquinoline-5-carboxamide 
• 939758-74-4 5-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline 
• 342-30-3 5-(trifluoromethyl)quinolone 
• 1257524-04-1 5-{5-[2-(4-chloro-phenoxymethyl)-phenyl]-[1,3,4]oxadiazol-2-yl}-quinoline 
• 1257524-03-0 C₂₅H₁₉N₃O₂ 
• 1029491-93-7 C₁₈H₈Cl₃N₅S 
• 858784-68-6 N-(quinoline-5-carbonyl)-N'-(toluene-4-sulfonyl)-hydrazine 
• 96541-83-2 quinoline-5-carbohydrazide 
• 118128-78-2 ethyl ester of 1,2,3,4-tetrahydroquinoline-5-carboxylic acid 
• 85403-69-6 dihydroisokomarovine 
• 98421-29-5 5-(2-benzamidoethyl)quinoline 

Relevant academic research and scientific papers

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

QUINOLYL AMIDE DERIVATIVES AS CCR-5 ANTAGONISTS

The present invention relates to a series of compounds which are CCR-5 receptor antagonists of the general formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.

HIV protease inhibitors

HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

HIV protease inhibitors

HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

Intermediate and process for making

The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.

ALKALOIDS OF Nitraria komarovii. VI. STRUCTURE AND SYNTHESIS OF ISOKOMAROVINE AND OF KOMAROVIDININE

Two new alkaloids, isokomarovine and komarovidinine, have been isolated from the epigeal part of the plant Nitraria komarovii Iljin et Lava.The passage from isokomarovine to komarovidinine has been performed.Their structures have been established on the basis of spectra and experimental facts: 1-(quinolin-5'-yl)-9H-pyridoindole and indoloquinolinonaphthyridine, respectively.Their synthesis has been performed.

ALKALOIDS OF Nitraria komarovii. VII. STRUCTURE AND SYNTHESIS OF KOMAROVININE

The new alkaloid komarovinine has been isolated from the total ether-extracted alkaloids of the epigeal part of Nitraria komarovii.It has also been found among the products of the dehydrogenation of nitrarine by selenium and sulfur.On the basis of the available facts, the structure of one of the isomers of 1-quinolinyl-β-carboline was proposed for komarovinine.A direct comparison with synthetic samples shows the identity of the alkaloid to 1-(quinolin-6'-yl)-β-carboline. 1-(Quinolin-7'-yl)-β-carboline, not previously described in the literature, has been characterized.