98477-40-8Relevant academic research and scientific papers
COMPOUNDS AND USES THEREOF
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Page/Page column 120-121, (2020/10/20)
The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.
COMPOUNDS AND USES THEREOF
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Page/Page column 113-114, (2019/10/15)
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
Pyridinone diketo acids: inhibitors of HIV replication
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Page/Page column 13, (2008/06/13)
A new class of diketo acids constructed on pyridinone scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents, especially other anti-HIV compounds (including other integrase-based anti-HIV agents). Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.
THERMOLYSIS OF N-BENZYL DERIVATIVES OF 2-AMINOPYRIDINES. A CHARGE SENSITIVITY (CS) AND MNDO STUDY OF ELECTROPHILIC SUBSTITUTION OF 2-AMINOPYRIDINES
Kowalski, Piotr
, p. 97 - 108 (2007/10/02)
The thermolysis reaction of N-mono (1,2) and N-disubstituted (3,4) benzyl derivatives of 2-aminopyridines were carried out at 250 deg C in order to verify the scheme of the reaction of 2-aminopyridines with electrophiles.N-Annular benzyl substituent in 1
Action of Benzyl Chloride on 2-(N,N-Dimethylamino)pyridine and 2-Benzoylaminopyridine
Kowalski, Piotr
, p. 245 - 248 (2007/10/02)
The results of the reaction of 2-(N,N-dimethylamino)pyridine (1) and 2-benzoylaminopyridine (2) with benzyl chloride (3) proved that 3 did not undergo direct reaction with the pyridine ring to form a C-benzyl product.
Electrophilic Benzylation of the Pyridine Ring. Action of Benzyl Chlorides on 2-Amino and 2-Benzylaminopyridine
Kowalski, Piotr
, p. 403 - 408 (2007/10/02)
The reaction of 2-aminopyridine as well as 2-benzylaminopyridine hydrochloride with benzyl chlorides used in molar ratio 1:2 and 1:1 respectively and carried out at 250 deg C leads via 2-benzylamino-5-benzylpyridines to 2-amino-5-benzylpyridines as the fi
Electrophilic Benzylation of 2-Aminopyridine Ring
Kowalski, Piotr
, p. 875 - 879 (2007/10/02)
In the reaction of 2-aminopyridine and its 3- or 5-methyl derivatives with benzyl chloride used in a molar ratio of 1:2, benzylation of 2-aminopyridine ring has been stated that 2-amino-3- or 5-benzylpyridines c as the major products were obtained.Formation of c type compounds took place in the decomposition of 2-benzylamino-3- or 5-benzylpyridines b obtained in the reaction of the 2-benzylaminopyridines a, excess benzyl chloride was used.Production of the b and c compounds, where the benzyl substituent occupied position 3 or 5 in 2-aminopyridine supported the electrophilic mechanism of the reaction (radical reaction was excluded).In the case of 2-aminopyridine and its 3-methyl derivative bis-(2-amino-5-pyridyl)phenylmethanes d were formed as the by-products.
Bisubstrate reaction templates. Examination of the consequences of identical versus different binding sites
Ross Kelly,Bridger, Gary J.,Zhao, Chen
, p. 8024 - 8034 (2007/10/02)
A reaction template (1≈9) possessing two binding sites is described. The template was designed to use hydrogen bonding to simultaneously (but transiently) bind two substrates, giving rise to a ternary complex (2≈12), which positions the substrates in an o
