98508-67-9Relevant academic research and scientific papers
Nitrosoarene-catalyzed regioselective aromatic C-H sulfinylation with thiols under aerobic conditions
Chatterjee, Indranil,Patel, Sandeep,Pradhan, Suman
supporting information, p. 5054 - 5057 (2020/05/18)
Aromatic amines and (hetero)arenes, such as indoles and pyrroles, are regioselectively sulfinylated under mild aerobic conditions using nitrosoarenes as a redox-catalyst. The nitrosoarene is involved in the electron transfer process with arenes to generate a crucial arene radical cation intermediate for C-H sulfinylation. The present methodology requires no directing group, can be scaled up easily and is applicable for the late-stage functionalization of drug molecules and natural products with high regioselectivity.
A 3 - indole aryl sulfoxide compound of preparation method (by machine translation)
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Paragraph 0019-0022; 0043-0044, (2019/06/07)
The invention provides a 3 - indole aryl sulfoxide compound of preparation method. Its steps are: the indole compound, sulfin amine compounds and accelerator dissolve in the organic solvent, under a certain temperature to stir until the reaction is comple
Regioselective and oxidant-free sulfinylation of indoles and pyrroles with sulfinamides
Ji, Yuan-Zhao,Zhang, Jin-Yu,Li, Hui-Jing,Han, Chunguang,Yang, Yi-Kun,Wu, Yan-Chao
, p. 4789 - 4800 (2019/05/24)
An unexpected time-controlled highly selective C3-or C2-sulfinylation of pyrroles with sulfinamides is reported for the first time. The sulfinylation of indoles with sulfinamides using this protocol is oxidant-free and can be performed under obviously more feasible conditions (1.2 equiv. of indoles, 10 min) in comparison with the precedent procedure (3-20 equiv. of indoles, 16-18 h, ammonium persulfate as oxidant, hv). A variety of functional groups were tolerated, and various C2-thioindoles and C2/3-thiopyrroles were obtained in moderate to excellent yields.
Dramatic influence of ionic liquid and ultrasound irradiation on the electrophilic sulfinylation of aromatic compounds by sulfinic esters
Nguyen, Ngoc-Lan Thi,Vo, Hong-Thom,Duus, Fritz,Luu, Thi Xuan Thi
, (2017/09/25)
The sulfinylation reaction of aromatic and hetero-aromatic compounds with sulfinic esters as electrophiles has been investigated in different ionic liquids and by means of different Lewis acid salts in order to get moderate to good yields of asymmetrical
Tert-Butyl Sulfoxide as a Starting Point for the Synthesis of Sulfinyl Containing Compounds
Wei, Juhong,Sun, Zhihua
supporting information, p. 5396 - 5399 (2015/11/18)
Sulfoxides bearing a tert-butyl group can be activated using N-bromosuccinimide (NBS) under acidic conditions and then subsequently treated with a variety of nitrogen, carbon, or oxygen nucleophiles to afford a wide range of the corresponding sulfinic acid amides, new sulfoxides, and sulfinic acid esters.
Nucleophilic ortho allylation of aryl and heteroaryl sulfoxides
Eberhart, Andrew J.,Imbriglio, Jason E.,Procter, David J.
supporting information; experimental part, p. 5882 - 5885 (2011/12/15)
Aryl and heteroaryl sulfoxides undergo ortho allylation upon treatment with Tf2O and allylsilanes. The method complements the use of sulfoxides to direct ortho-metalation and reaction with electrophiles as it allows allylic carbon nucleophiles to be added ortho to the directing group in a metal-free process. The versatile sulfide adducts can be selectively manipulated using various methods including Kumada-Corriu cross-coupling of the organosulfanyl group.
A NOVEL SYNTHESIS OF 3-CYANOINDOLES AND A NEW ROUTE TO INDOLE-3-CARBOXYLIC ACID DERIVATIVES.
Garcia, Josefina,Greenhouse, Robert,Muchowski, Joseph M.,Ruiz, Jose Antonio
, p. 1827 - 1830 (2007/10/02)
2-Alkyl-3-cyanoindoles are obtained when 1-alkylmethyl-2-chloro-(or 2-phenylsulfonyl)-3-phenylsulfonylindoles are reacted with excess azide ion (90 deg C/DMF).The reaction is considered to occur by a fragmentation recombination process in which the Schiff
