98526-50-2

Upstream product

• 98526-44-4 5-(4-Benzoylpiperazin-1-yl)-2-nitroaniline 
• 13754-38-6 N-Benzoylpiperazine 
• 1635-61-6 5-chloro-2-nitroaniline 
• 96103-52-5 2-nitro-5-piperazin-1-yl-phenylamine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 98526-58-0 [6-(4-Benzoyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-carbamic acid ethyl ester 
• 98526-57-9 methyl 5⁽⁶⁾-(4-benzoylpiperazin-1-yl)benzimidazole-2-carbamate 

Relevant academic research and scientific papers

Synthesis and potential anthelmintic activity of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates

A series of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates (IX) has been prepared. 5-(4-salicyloyl-piperazin-1-yl)-2-nitro anilines (VII) have been synthesized starting from 5-piperazino-2-nitro anilines and salicyloyl chlorides. Catalytic reduction of VII with Pd/C, followed by treatment with 1,3-dicarbomethoxy-S-methyl isothiourea, yielded the corresponding carbamates (IX), the anthelmintic activity of which was studied. Compound IX(a) significantly reduced the numbers of preadults, adults and encysted T. spiralis larvae in experimental mice.

Synthesis and anthelmintic activity of 5(6)-(benzimidazol-2-ylcarbamoyl) and (4-substituted piperazin-1-yl)benzimidazoles

The synthesis of alkyl 5(6)-(benzimidazol-2-ylcarbamoyl)benzimidazole-2-carbamates and alkyl 5(6)-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (31-40) has been carried out. When the compounds were tested for their anthelmintic activity against