98534-71-5

Usage

Uses

Used in Organic Synthesis:
5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester is utilized as a key intermediate in organic synthesis for the preparation of a variety of chemical entities. Its unique structure allows for further functionalization and modification, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester is employed as a precursor in the development of new drugs. Its potential in exhibiting diverse pharmacological properties positions it as a promising candidate for drug discovery, where it can be used to explore and create novel therapeutic agents.
Used in Medicinal Chemistry Research:
5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester is also used as a research tool in medicinal chemistry. It aids scientists in understanding the structure-activity relationships of potential drug molecules, thereby facilitating the optimization of drug candidates for enhanced efficacy and safety profiles.
Overall, 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester is a multifaceted chemical with applications spanning across various scientific disciplines, particularly in the development and synthesis of new pharmaceuticals and organic compounds.

Upstream product

• 116344-09-3 2-dimethylaminomethylene-4-methyl-3-oxo-pentanoic acid ethyl ester 
• 100-63-0 phenylhydrazine 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 13183-09-0 3-phenyl-4-bromosydnone 
• 623-47-2 propynoic acid ethyl ester 
• 508191-77-3 3-phenylsydnone 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 
• 110-46-3 isopentyl nitrite 

Downstream Products

• 54367-65-6 5-bromo-1-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation

Dysregulation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Although numerous Wnt inhibitors have been developed, they commonly suffer from toxicity and unintended effects. Moreover, concerns have been raised in targeting this pathway because of its critical roles in maintaining stem cells and regenerating tissues and organs. On the basis of the anthelmintic drug pyrvinium and previous lead FX1128, we have developed a compound YW2065 (1c) which demonstrated excellent anti-CRC effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. The anti-CRC effect of YW2065 was highlighted by its promising efficacy in a mice xenograft model.

Copper(I)-catalyzed cycloaddition of 4-bromosydnones and alkynes for the regioselective synthesis of 1,4,5-trisubstituted pyrazoles

Copper-catalyzed cycloaddition of alkynes with 4-bromosydnones provides a convenient, mild, and regioselective method for the synthesis of a wide range of bromopyrazoles. The broad functional group tolerance of the cycloaddition reaction and further palla

Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides

1,5-Disubstituted-1H-pyrazole-4-carboxamide derivatives, useful as herbicides and aquatic algicides.