98540-06-8

Upstream product

• 98540-05-7 dichlorocyclobutanone 
• 488856-90-2 2-chloro-2,3-dimethyl-cyclohexanone 
• 1502-24-5 2,3-dimethylcyclohexan-1-ol 
• 1759-64-4 1,6-dimethyl-1-cyclohexene 
• 98540-10-4 Acetic acid (1S,2R,6R)-8-chloro-1,2-dimethyl-bicyclo[4.2.0]oct-7-en-7-yl ester 

Downstream Products

• 98540-12-6 (+/-)-(1R,2S,6S)-1,2-bis(iodomethyl)-1,6-dimethylcyclohexane 
• 98540-11-5 (1RS,2SR,3SR)-2-(hydroxymethyl-2,3-dimethylcyclohexyl)methanol 
• 147728-51-6 (1R,2S,6S)-1,6-Dimethyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester 
• 19906-72-0 (+/-)-7-epi-bakkenolide A 
• 19906-72-0 (+/-)-bakkenolide A 

Relevant academic research and scientific papers

An Approach to the Bakkanes. A Short, Stereocontrolled Total Synthesis of (+/-)-Bakkenolide A

A stereoselective total synthesis of (+/-)-bakkenolide A (fukinanolide) has been efficiently achieved in six steps.

First comprehensive bakkane approach: Stereoselective and efficient dichloroketene-based total syntheses of (±)- and (-)-9-acetoxyfukinanolide, (±)- and (+)-bakkenolide a, (-)-bakkenolides III, B, C, H, L, V, and X, (±)- and (-)-homogynolide A, (±)-homogynolide B, and (±)-palmosalide C

Cycloaddition of dichloroketene with dimethylcyclohexenes has been used as the key reaction in an efficient, general approach to the bakkanes. New methods and methodologies that have been developed in this work include spiro β-methylene-γ-butyrolactonizations, a vicinal dicarboxylation, an angelic ester preparation, a transesterification, an epoxy ketone double reduction, and a retro aldol-aldol approach to low-energy aldol isomers.