98560-25-9

Basic information

• Product Name: 2,2-DIPROPYL-OXIRANE
• Synonyms: 2,2-DIPROPYL-OXIRANE
• CAS NO: 98560-25-9
• Molecular Formula: C₈H₁₆O
• Molecular Weight: 128.21204
• Mol File: 98560-25-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-DIPROPYL-OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIPROPYL-OXIRANE(98560-25-9)
• EPA Substance Registry System: 2,2-DIPROPYL-OXIRANE(98560-25-9)

Safety Data

• Hazardous Substances Data: 98560-25-9(Hazardous Substances Data)

Usage

General Description

2,2-Dipropyl-oxirane, also known as propylene oxide, is a chemical compound with the molecular formula C6H12O. It is a colorless, flammable liquid with a mildly sweet odor, commonly used as a chemical intermediate in the production of various industrial and consumer products. 2,2-Dipropyl-oxirane is primarily used in the manufacture of polyurethane foam, which is used in furniture, bedding, and automotive applications. It is also utilized as a solvent in various processes and as a fumigant for stored grains and soil. Additionally, it is used in the production of fuel additives, pharmaceuticals, and personal care products. However, 2,2-Dipropyl-oxirane is considered to be a potential carcinogen and has been associated with adverse health effects, so proper handling and safety precautions are necessary when working with this chemical.

Upstream product

• 18021-17-5 4-chloromethyl-heptan-4-ol 
• 15918-08-8 2-propyl-1-pentene 
• 123-19-3 4-heptanone 
• 2181-42-2 trimethylsulphonium iodide 
• 927-77-5 n-propylmagnesium bromide 
• 105-39-5 chloroacetic acid ethyl ester 
• 1774-47-6 trimethylsulfoxonium iodide 

Downstream Products

• 60729-41-1 4,4-dipropylcyclohex-2-en-1-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 126443-73-0 (2-Hydroxy-2-propyl-pentyl)-triphenyl-phosphonium; bromide 
• 15918-08-8 2-propyl-1-pentene 
• 18295-59-5 2-propylpentanal 

Relevant articles and documents

Substituent and Lewis Acid Promoted Dual Behavior of Epoxides towards [3+2]-Annulation Reactions with Donor-Acceptor Cyclopropanes: Synthesis of Substituted Cyclopentane and Tetrahydrofuran

Substituent and Lewis acid promoted generation of functionalized enolates from epoxides is developed. Divergent attack of the enolate on donor-acceptor cyclopropanes, i.e. C-attack or O-attack depending upon substituents present in both reacting partners, produced different products. C-attack gave functionalized cyclopentane derivatives, whereas O-attack furnished tetrahydrofuran derivatives through [3+2]-annulation reactions. Moreover, to increase the utility of our method, synthesized diastereomeric cyclopentane derivatives were converted into synthetically useful cyclopentene and cyclopentanone analogs.

ALKOXY COMPOUNDS FOR DISEASE TREATMENT

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Antiarthritic and suppressor cell inducing activity of azaspiranes: Structure-function relationships of a novel class of immunomodulatory agents

Spirogermanium (1;8,8-diethyl-N,N-dimethyl-2-aza-8-germaspiro[4.5]decane-2-propanamin e dihydrochloride) is a potent cytotoxic agent in vitro which has demonstrated limited activity in experimental animal tumor models. Subsequently, it has been reported that spirogermanium has antiarthritic and suppressor cell-inducing activity. We have synthesized a series of substituted 8-hetero-2-azaspiro[4.5]decane and 9-hetero-3-azaspiro[5.5]undecane analogues of spirogermanium to identify the heteroatom requirements for in vivo antiarthritic and suppressor cell-inducing activity. This structure-activity relationship study has identified that appropriately substituted silicon and carbon analogues of spirogermanium retain both antiarthritic and immunosuppressive activity, with the 8,8-dipropyl (carbon) analogue being among the most active. Following the identification of N,N-dimethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dihydrochloride (9) as more active analogue than spirogermanium, a series of 8,8-dipropyl analogues with various amine substituents were synthesized. A number of these analogues had activity similar to that of 9. A correlation between activity in the adjuvant arthritic rat and the ability to induce suppressor cells (r = 0.894, p0.001) suggests an association between the two pharmacologic effects. While the precise biochemical mechanism(s) for the pharmacological activity is unclear, these data suggest that compounds within this series, e.g., N,N-dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride, may provide effective therapy in diseases of autoimmune origin and/or the prevention of rejection in tissue transplantation.