98581-85-2Relevant academic research and scientific papers
Synthesis and antibacterial evaluation of 2-ethyl-1-(4-substituted)phenyl- 1h-imidazole derivatives as open-chain analogues of 7-Alkoxyl-4,5-dihydro-imidazo[1,2-A]quinolines
Sun, Xian-Yu,Liu, Mei-Yu,Zhong, Chun-Yan,Zheng, Gui-Lin,Lv, Ming-Yue,Jing, Bo Tao,Pan, Chun-Yuan,Wang, Xin
, p. 701 - 707 (2018)
A novel series of 2-ethyl-1-(4-substituted)phenyl-1H-imidazole derivatives was designed, synthesized, and tested for its antibacterial activity against various bacterial strains. Most of the synthesized compounds showed potent inhibition of several Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the range of 4 256 nmol mL-1 in vitro. The compound [2-ethyl-1-(4-pentoxy)phenyl-1H-imidazole] exhibited the most potent inhibitory activity. The MIC of this compound against S. aureus was found to be 8 nmol mL-1, smaller than that of the reference agents, ciprofloxacin and amoxicillin. Furthermore, the compound exhibited modest activity against several bacterial strains in a dose range of 8 256 nmol mL-1.
1-substituted phenyl-2-alkylimidazole derivatives and applications thereof
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, (2017/07/20)
The invention relates to 1-substituted phenyl-2-alkylimidazole derivatives expressed in the general formula (I) as shown in the specification and usable salts thereof, wherein R represents a straight chain or branched chain C1-C12 alkyl, phenyl or halogenated benzene; R1 represents straight chain or branched chain C1-C12 alkyl, halogenated phenmethyl or alkyl substituted phenmethyl. The invention further provides a pharmaceutical composition comprising the derivative and salts thereof, and applications of the derivative and salts thereof in preparation of antibacterial drugs. The derivative and salts thereof play a role in inhibiting staphylococcus aureus and Escherichia coli, and other gram-negative bacteria (such as pseudomonas aeruginosa, klebsiella pneumoniae, proteusbacillus vulgaris, salmonella, pasteurella and the like) and multiple gram-positive bacteria, and can be used for preparing antibacterial drugs.
