98589-71-0Relevant academic research and scientific papers
Pd-catalyzed decarboxylative cross-coupling of sodium pyrimidinecarboxylates with (hetero)aryl bromides
Wang, Shengqiang,Lu, Hongtao,Zou, Dapeng,Wu, Yangjie,Li, Jingya,Wu, Yusheng,Zou, Dapeng,Wu, Yusheng,Li, Jingya
supporting information, p. 2723 - 2726 (2017/06/23)
A straightforward method for the synthesis of functionalized 4- or 5-(hetero)arylpyrimidines via decarboxylative cross-coupling reaction from readily available pyrimidine-4- and pyrimidine-5-carboxylates was described. In the presence of dual-catalyst system of Pd(PPh3)4/Cu2O, the reaction proceeds smoothly, tolerates a variety of functional groups, and provides easy access to the synthesis of different (hetero)arylpyrimidines compounds.
Direct access to pyrimidines through organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine
Yang, Gongming,Jia, Qianfa,Chen, Lei,Du, Zhiyun,Wang, Jian
, p. 76759 - 76763 (2015/09/28)
An organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine through enamine catalysis has been developed. This method could furnish 4,5-disubstituted pyrimidines in good yields and high levels of regioselectivities.
Indolizines and pyrrolo[1,2-c]pyrimidines decorated with a pyrimidine and a pyridine unit respectively
Popa, Marcel Mirel,Georgescu, Emilian,Caira, Mino R.,Georgescu, Florentina,Draghici, Constantin,Stan, Raluca,Deleanu, Calin,Dumitrascu, Florea
, p. 1079 - 1088 (2015/08/18)
The three possible structural isomers of 4-(pyridyl)pyrimidine were employed for the synthesis of new pyrrolo[1,2-c]pyrimidines and new indolizines, by 1,3-dipolar cycloaddition reaction of their corresponding N-ylides generated in situ from their corresp
One-pot and three-component synthesis of substituted pyrimidines catalysed by boron sulfuric acid under solvent-free conditions
Soheilizad, Mehdi,Adiba, Mehdi,Sajjadifarb, Sami
, p. 524 - 527 (2014/12/10)
An efficient, simple and one-pot synthesis of pyrimidine derivatives by a three-component reaction of ketones, triethyl orthoformate, and ammonium acetate in the presence of boron sulfuric acid as a reusable and efficient catalyst under solvent-free conditions is reported. The reusability of catalyst, simplicity of the starting materials, short reaction time, one-pot, and good yields of products are the main advantages.
One-pot synthesis of pyrimidines under solvent-free conditions
Ghorbani-Vaghei, Ramin,Karimi-Nami, Rahman,Toghraei-Semiromi, Zahra,Amiri, Mostafa,Salimi, Zahra,Ghavidel, Mehdi
, p. 324 - 330 (2014/04/17)
N,N,N',N'-Tetrabromobenzene-1,3-disulfonamide was used as an efficient catalyst for the one-pot synthesis of pyrimidine derivatives in excellent yields from triethoxymethane, ammonium acetate, and various ketone derivatives at 100-110 °C under solvent-fre
Novel synthesis of bihetaryl compounds
Nishiwaki, Nagatoshi,Yamashita, Keiko,Azuma, Mayumi,Adachi, Tomoko,Tamura, Mina,Ariga, Masahiro
, p. 1996 - 2000 (2007/10/03)
The ring transformation of nitropyrimidinone 1 with acetophenone derivatives 2 affords two kinds of azaheterocyclic compounds, 4-phenylpyrimidines 3 and 3-nitro-6-phenyl-2-pyridones 4. On the basis of the relationship between electronic properties of the substituent and ratios of products, a plausible reaction mechanism is provided. Furthermore, the present reaction could be applied to heterocyclic ketones giving bihetaryl compounds.
