98684-31-2

Upstream product

• 18800-32-3 1-(2-bromoethoxy)-2-methylbenzene 
• 124-41-4 sodium methylate 
• 41532-81-4 2-methoxyethyl phenyl ether 
• 74-88-4 methyl iodide 
• 108-95-2 phenol 
• 95-48-7 ortho-cresol 
• 6482-24-2 2-Bromoethyl methyl ether 

Downstream Products

• 114985-34-1 4-chloromethyl-1-(2-methoxy-ethoxy)-2-methyl-benzene 
• 69129-46-0 4-(2-methoxy-ethoxy)-3-methyl-benzenesulfonyl chloride 
• 39085-58-0 2-(2-methoxyethoxy)-1,3-dimethylbenzene 
• 95-48-7 ortho-cresol 
• 1042314-37-3 1-[2-(2-methoxyethoxy)phenyl]-pentan-3-ol 
• 1042314-24-8 2-[2-(2-methoxyethoxy)phenyl]-1,1-diphenylethanol 
• 14003-84-0 4-(2-hydroxyphenyl)-1-butene 
• 90-00-6 o-Hydroxyethylbenzene 

Relevant academic research and scientific papers

New stabilising groups for lateral lithiation of ortho-cresol derivatives and a new route to 2-substituted chromans

2-(2-Methoxyethoxy)-toluene and 2-(2-dimethylaminoethoxy)-toluene have been lithiated using sec-BuLi under a variety of conditions and the laterally lithiated species trapped with electrophiles, including but-1-ene oxide, leading to a new synthesis of 2-ethylchroman.

ortho-Directed Lithiation of (2-Methoxy)ethoxy- and (2-Dimethylamino)ethoxy-arenes

ortho-Directed lithiation of a number of (2-methoxy)ethoxy- and (2-dimethylamino)ethoxy-arenes has been investigated.Lithiation of these compounds followed by treatment with various electrophiles afforded ortho-substituted products in moderate to excellent yields.Keywords-ortho-directed lithiation; (2-methoxy)ethoxyarene; (2-dimethylamino)ethoxyarene; regioselectivity