987-65-5

Basic information

• Product Name: Adenosine 5'-triphosphate disodium salt
• Synonyms: ADENOSINE TRIPHOSPHATE DISODIUM;ADENOSINE TRIPHOSPHATE, DISODIUM SALT;ADENYLPYROPHOSPHORIC ACID DISODIUM SALT;ADENOSINE-5'-TRIPHOSPHATE HYDRATE DISODIUM SALT;ADENOSINE-5'-TRIPHOSPHATE NA2-SALT;ADENOSINE-5'-TRIPHOSPHORIC ACID, DISODIUM;ADENOSINE-5'-TRIPHOSPHORIC ACID DISODIUM DIHYDROGEN SALT;ADENOSINE 5'-TRIPHOSPHORIC ACID DISODIUM SALT
• CAS NO: 987-65-5
• Molecular Formula: C₁₀H₁₄N₅O₁₃P₃*2Na
• Molecular Weight: 551.14
• EINECS: 213-579-1
• Product Categories: Nucleotides and their analogs;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;Bases & Related Reagent;Carbohydrates & Derivatives;Heterocycles;Metabolites & Impurities;Nucleotides;Phosphorylating and Phosphitylating Agents;Carbohydrates & Derivatives, Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagent, Phosphorylating and Phosphitylating Agents;Material
• Mol File: 987-65-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 188～190℃
• Boiling Point: 951.4 °C at 760 mmHg
• Flash Point: 529.2 °C
• Appearance: /crystalline
• Density: 2.63g/cm3
• Vapor Pressure: 0.1Pa at 20-50℃
• Storage Temp.: 2-8°C
• Solubility: H2O: 50 mg/mL
• Water Solubility: Soluble in water
• Merck: 155
• CAS DataBase Reference: Adenosine 5'-triphosphate disodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine 5'-triphosphate disodium salt(987-65-5)
• EPA Substance Registry System: Adenosine 5'-triphosphate disodium salt(987-65-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• RTECS: AU7417000
• F: 10-21
• Hazardous Substances Data: 987-65-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Different sources of media describe the Uses of 987-65-5 differently. You can refer to the following data:
1. A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism. ATP Disodium Salt is used in the synthetic preparation of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands.
2. Adenosine 5'-triphosphate disodium salt is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.ATP (Adenosine-Triphosphate) transports chemical energy within cells for metabolism. ATP (Adenosine-Triphosphate) is produced by photophosphoryla.
3. In biochemical research. To inhibit enzymatic browning of raw edible plant materials, such as sliced apples, potatoes, etc.

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is an important energy currency in all living organisms. It possesses high phosphate transfer potential. ATP is involved in several biological processes such as membrane transport, muscle contraction and synthesis, and degradation of biological molecules. It plays a role as an intracellular and extracellular signaling molecule in certain cellular processes such as cell motility, organ development, neurotransmission, and insulin secretion.

Upstream product

• 7659-75-8 adenosine (5'-phosphoro-1-piperidinide) 
• 79670-88-5 C₁₀H₁₆N₅O₁₃P₃*4H₃N 
• 33962-65-1 adenosine 5'-phosphate triethylammonium salt 
• 1577254-51-3 adenosine 5′-phosphoropiperidate triethylammonium salt 
• 4578-31-8 adenosine-5'-monophosphate disodium salt 
• 1172-42-5 adenosine-5′-diphosphate trisodium salt 
• 58-61-7 adenosine 
• 34051-17-7 C₁₀H₁₂Cl₂N₅O₅P 
• 53355-60-5 adenosine 5'-trimetaphosphate 

Downstream Products

• 58-64-0 adenosine 5'-diphosphate 
• 61-19-8 5'-adenosine monophosphate 

Relevant articles and documents

Concurrent Prebiotic Formation of Nucleoside-Amidophosphates and Nucleoside-Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization

Polymerization of nucleic acids in biology utilizes 5′-nucleoside triphosphates (NTPs) as substrates. The prebiotic availability of NTPs has been unresolved and other derivatives of nucleoside-monophosphates (NMPs) have been studied. However, this latter approach necessitates a change in chemistries when transitioning to biology. Herein we show that diamidophosphate (DAP), in a one-pot amidophosphorylation-hydrolysis setting converts NMPs into the corresponding NTPs via 5′-nucleoside amidophosphates (NaPs). The resulting crude mixture of NTPs are accepted by proteinaceous- and ribozyme-polymerases as substrates for nucleic acid polymerization. This phosphorylation also operates at the level of oligonucleotides enabling ribozyme-mediated ligation. This one-pot protocol for simultaneous generation of NaPs and NTPs suggests that the transition from prebiotic-phosphorylation and oligomerization to an enzymatic processive-polymerization can be more continuous than previously anticipated.

Efficient synthesis of nucleoside 5′-triphosphates and their β,γ-bridging oxygen-modified analogs from nucleoside 5′-phosphates

Thirteen nucleoside 5′-triphosphates (NTPs) and their β,γ-bridging oxygen-modified analogs (β,γ-CX 2-NTPs, X = H, F, Cl, and Br) have been efficiently synthesized from nucleoside 5′-phosphoropiperidates with 4,5-dicyanoimidazole as the activator. A high-yielding and chromatography-free protocol for the preparation of both natural and base-modified nucleoside 5′-phosphoropiperidates from the corresponding nucleoside 5′-phosphates was also developed.

Convenient synthesis of nucleoside 5′-triphosphates for RNA transcription

By generating a selective phosphitylating reagent in situ, nucleoside 5′-triphosphates can be conveniently synthesized in one pot. This novel strategy without nucleoside protection has been developed to largely simplify synthesis of the nucleoside triphosphates. This demonstrated principle can be applied to the 5′-triphosphate synthesis of both native and modified nucleosides.