98700-53-9

Usage

Uses

Used in Pharmaceutical Research:
1,5-Diphenyl-1H-pyrazole-4-carboxylic acid is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs with diverse therapeutic effects.
Used in Agrochemical Development:
In the agrochemical industry, 1,5-Diphenyl-1H-pyrazole-4-carboxylic acid is used as a starting material for the creation of new agrochemicals, potentially enhancing crop protection and yield.
Used in Organic Synthesis:
As a building block in organic synthesis, 1,5-Diphenyl-1H-pyrazole-4-carboxylic acid is utilized for the preparation of a variety of compounds with potential applications across different fields.
Used in Anti-inflammatory Applications:
1,5-Diphenyl-1H-pyrazole-4-carboxylic acid is studied for its potential anti-inflammatory properties, which could be harnessed in the development of treatments for inflammatory conditions.
Used in Antimicrobial Applications:
1, 5-Diphenyl-1H-pyrazole-4-carboxylic acid is also being investigated for its antimicrobial properties, suggesting its use in the development of new antibiotics or antifungal agents to combat resistant strains.
Used in Anticancer Research:
1,5-Diphenyl-1H-pyrazole-4-carboxylic acid is explored for its potential anticancer properties, indicating its use in cancer research and the development of novel therapeutic agents for cancer treatment.

Upstream product

• 53561-07-2 1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 35280-08-1 1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid 
• 59-88-1 phenylhydrazine hydrochloride 
• 39973-76-7 ethyl 2-benzoyl-3-ethoxyacrylate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 6831-89-6 1,5-diphenyl-1H-pyrazole 
• 502935-52-6 1,5-diphenyl-1H-pyrazole-4-carboxylic acid methoxy-amide 

Relevant academic research and scientific papers

Synthesis and Rotational Isomerism of 1-Substituted Methyl (S)-[5-(2-Nitrophenyl)-1H-pyrazole-4-carbonyl]alaninates

Seven title compounds 12a-g and the (S)-prolinate analogue 13 were prepared in five steps from 2-nitrobenzoic acid (7). Reduction of the nitro group followed by derivatization of the so formed anilines 14 gave the N-alkyl-(15a-c), N-acyl-(16a,b and 19), and N-vinyl derivative 20. NMR spectra of (S)-alanine and (S)-proline derived compounds 12, 13, 14-16, 19, and 20 exhibited two sets of signals corresponding to pairs of conformational diastereomers. The free energy barriers of rotation, ΔG?298 = 82-86 kJ mol-1, were determined by 1H NMR for 12a, 12d, 12f, and 12g and evaluated by DFT calculations.

Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004

New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.

Synthesis and characterization of some pyrazole derivatives of 1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid

(Chemical Equation Presented) Compound of 4-(ethoxycarbonyl)-1,5-diphenyl- 1H-pyrazole-3-carboxylic acid 2 was obtained from the reaction of ethyl 4,5-dioxo-2-phenyl-4,5-dihydrofuran-3-carboxylate and 1-benzylidene-2- phenylhydrazine. A number of substitute pyrazole dicarboxylic acid derivatives (4, 5a-c, 6, 7, 8, 9a-m, 10, 11, 12, 13, 14) were synthesized from 1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid 3 which was prepared from basic hydrolysis of 2. Structures of synthesized compounds were characterized by 1H NMR, 13C NMR, Mass, FTIR, and elemental analysis.

A general and efficient PIFA mediated synthesis of heterocycle-fused quinolinone derivatives

A new application of the hypervalent iodine reagent phenyliodine(III)bis(trifluoroacetate) (PIFA) has been developed for the construction of a series of N, O, S-containing heterocycle-fused quinolinone derivatives in a general and efficient way. An altern