98711-43-4

Basic information

• Product Name: 1H-Pyrazole-5-carboxamide,1-methyl-(9CI)
• Synonyms: 1H-Pyrazole-5-carboxamide,1-methyl-(9CI);2-methyl-3-pyrazolecarboxamide;2-methylpyrazole-3-carboxamide
• CAS NO: 98711-43-4
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.12858
• Product Categories: AMIDE
• Mol File: 98711-43-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 349.324 °C at 760 mmHg
• Flash Point: 165.066 °C
• Appearance: /
• Density: 1.346 g/cm³
• Vapor Pressure: 4.74E-05mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 1H-Pyrazole-5-carboxamide,1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-5-carboxamide,1-methyl-(9CI)(98711-43-4)
• EPA Substance Registry System: 1H-Pyrazole-5-carboxamide,1-methyl-(9CI)(98711-43-4)

Safety Data

• Hazardous Substances Data: 98711-43-4(Hazardous Substances Data)

Usage

Structure

A five-membered ring with three carbon atoms and two adjacent nitrogen atoms, with a carboxamide group attached to the 5-position and a methyl group attached to the 1-position.

Use

Primarily used as an intermediate in the synthesis of various drugs, particularly those with antifungal, antiviral, and antitumor properties.

Potential applications

May have potential applications in the development of new agricultural chemicals.

Safety precautions

It is important to handle this compound with care and to follow all safety precautions, as its specific hazards and risks have not been fully characterized.

Research status

Has potential as a building block for the preparation of biologically active compounds, but further research is needed to fully understand its properties and potential uses.

InChI:InChI=1/C5H7N3O/c1-8-4(5(6)9)2-3-7-8/h2-3H,1H3,(H2,6,9)

Upstream product

• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 17827-60-0 methyl 1-methyl-1H-pyrazole-5-carboxylate 

Downstream Products

• 863548-52-1 C-(2-methyl-2H-pyrazol-3-yl)methyl amine 

Relevant articles and documents

Palladium-Catalyzed C-N Coupling of Pyrazole Amides with Triazolo- And Imidazopyridine Bromides in Ethanol

An efficient palladium-catalyzed coupling between a pyrazole amide and a heteroaryl bromide was developed to enable the streamlined synthesis of a lead candidate for schizophrenia treatment. Process robustness and scalability were achieved using ethanol a

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Nucleophilic Substitution in Quaternary Salts of NN'-Linked Biazoles and Related Systems.

Some reactions of dicationic and monocationic N,N'-linked biazoles and of quaternized 1-(N-azolyl)pyridinium ions with nucleophiles have been studied.Although the pyrrolyl nucleus has been found to be a poor leaving group in these reactions, in other cases nucleophilic attack readily takes place at an azolyl carbon atom, with subsequent elimination of the N-substituent.The 1-methyl-3-(1-methyl-1,2,4-triazol-4-ylio)benzimidazolium dication (1) reacted at room temperature with ammonium, diethylamine, methoxyde, hydroxide, and cyanide ions, and with sodium borohydride, giving in all cases the corresponding 2-substituted benzimidazoles in good yield.In the case of the 2,4,6-trimethyl-1-(2-methylpyrazol-1-io)pyridinium dication (6), the reaction with cyanide ion afforded, regioselectively, 5-cyano-1-methylpyrazole, with no trace of the isomeric 3-cyano-1-methylpyrazole.The synthesis of the cations and dications from N-aminoazoles was easily performed.The reaction of 1-aminobenzimidazole with dehydroacetic acid in aqueous hydrochloric acid gave not only the expected 1-benzimidazol-1-yl-2,6-dimethylpyridin-4(1H)-one (9), but also 3-acetyl-1-benzimidazol-1-yl-4-hydroxy-6-methylpyridin-2(1H)-one (11).In pyridine, a pyran-2,4-dione intermediate (10), isomeric to (11), was also isolated.The quaternization reactions were easily performed, but high temperatures caused cleavage of the N-N bond.