98760-37-3

Upstream product

• 22529-61-9 (1R)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro(2,3-d)(1,3)dioxol-5-yl)ethane-1,2-diol 
• 34370-91-7 3-O-benzyl-1,2-O-isopropylidene-α-D-xylofuranose 
• 18685-18-2 3-O-benzyl-1,2-5,6-O-diisopropylidene-α-D-glucofuranose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 100-39-0 benzyl bromide 
• 6228-47-3 n-propyltriphenylphosphonium bromide 
• 23558-05-6 3-O-benzyl-1,2-O-isopropylidene-1,5-D-xylo-dialdofuranose 
• 16666-78-7 propylidenetriphenylphosphorane 

Downstream Products

• 1428859-96-4 C₁₆H₂₂O₄ 
• 1428859-97-5 (2R,3S,4R)-3,4-bis(benzyloxy)-2-((Z)-but-1-en-1-yl)-5-methoxytetrahydrofuran 
• 1543148-21-5 (2S,3S,4R,Z)-3-(benzyloxy)oct-5-ene-1,2,4-triol 
• 1543148-26-0 (3R,6S,7S,E)-ethyl 6-(benzyloxy)-3-ethyl-7,8-dihydroxyoct-4-enoate 
• 1543148-29-3 (3R,6S,7S,E)-ethyl 6-(benzyloxy)-3-ethyl-7-hydroxy-8-(tosyloxy)oct-4-enoate 
• 1543148-32-8 (3R,6S,7S,E)-6-(benzyloxy)-3-ethyloct-4-ene-1,7-diol 
• 1543148-33-9 (2S,3S,6R,E)-3-(benzyloxy)-6-ethyl-8-iodooct-4-en-2-ol 
• 1543148-35-1 ((2S,3S,6R,E)-6-ethyl-8-iodooct-4-ene-2,3-diyl)bis(oxy)bis(methylene)dibenzene 
• 1543148-38-4 (4R,7S,8S,E)-7,8-bis(benzyloxy)-4-ethyl-10-methylundeca-5,9-dienenitrile 
• 1543148-40-8 (4R,7S,8S,E)-7,8-bis(benzyloxy)-4-ethyl-10-methylundeca-5,9-dienal 
• 1543148-52-2 tert-butyl-(5-((4R,7S,8S,E)-7,8-bis(benzyloxy)-4-ethyl-10-methylundeca-5,9-dienoyl)-1,4,6-trimethoxy-7-methylnaphthalen-2-yl)carbamate 
• 1543148-24-8 (1S,2R,Z)-1-(benzyloxy)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)hex-3-en-2-ol 
• 1543148-25-9 (3R,6S,E)-ethyl 6-(benzyloxy)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-ethylhex-4-enoate 
• 98760-38-4 methyl 3-O-benzyl-5-deoxy-5-C-(n-propyl)-α-D-xylofuranoside 

Relevant academic research and scientific papers

Studies towards the total synthesis of hygrocins A and B

The western segment of hygrocins A-B has been synthesized through the coupling of a chiral C5-C13 synthon with the sterically demanding hexasubstituted naphthalenic core. The C5-C13 chiral fragment has been assembled via a stereoselective Johnson orthoest

Studies toward total synthesis of divergolides C and D

A facile synthesis of the western segment of divergolides C and D has been developed. Exploratory studies with two disconnections, i.e., C4-C5 vs C5-C6, for elaboration of the ansa bridge to the sterically demanding hexasubstituted naphthalenic aromatic c

Synthesis and biological activity of LL-P880γ and its analogues

Stereoisomers and analogues of LL-P880γ (2) were synthesized and tested to elucidate its structure-activity relationship. Their evaluation in the gibberellin-synergistic assay with rice seedlings revealed a clear dependence of potency on the stereochemist

Synthesis of Bis-γ-lactones from "Diacetone Glucose". 5. Optically Active Canadensolide

Details are given for the synthesis of optically active canadensolide.Use of "diacetone glucose" as the precursor affords the naturally occurring levorotatory enantiomer in 16 steps.The absolute configuration has been determined to be 2S,3R,4R.The investigation has revealed that the readily obtainable bis-lactone 10b is not a suitable intermediate for α-methylenation, since deprotonation with kinetic bases occurs preferentially at the methine position (C-2), which results in β-elimination.In the successful synthesis, the lactonic hemiacetal 10a emerges as the precursor of choice.