76857-06-2

Basic information

• Product Name: 1-BENZYL-2',3'-DIHYDROSPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-4'(1'H)-ONE
• Synonyms: 1-BENZYL-2',3'-DIHYDROSPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-4'(1'H)-ONE
• CAS NO: 76857-06-2
• Molecular Formula: C₁₉H₂₁N₃O
• Molecular Weight: 307.39
• Mol File: 76857-06-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZYL-2',3'-DIHYDROSPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-4'(1'H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-2',3'-DIHYDROSPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-4'(1'H)-ONE(76857-06-2)
• EPA Substance Registry System: 1-BENZYL-2',3'-DIHYDROSPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-4'(1'H)-ONE(76857-06-2)

Safety Data

• Hazardous Substances Data: 76857-06-2(Hazardous Substances Data)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 202826-52-6 IMT009 
• 1347747-66-3 C₂₀H₂₃N₃S 
• 1347747-64-1 C₁₉H₂₂N₄ 
• 1347747-62-9 C₂₀H₂₃N₃ 
• 98767-79-4 1-benzyl-4-(3,4-dihydro-2,2-dioxo-1H-2,1,3-benzothiadiazin-1-yl)piperidine 
• 98754-24-6 threo-1-<2-acetoxy-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 79106-38-0 threo-1-<2-hydroxy-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 79106-37-9 1-<2-oxo-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 79106-35-7 1-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one 
• 79106-33-5 1-(3,4-dimethoxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-1-yl]-piperidine 
• 98754-22-4 1-{1-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one 
• 98754-18-8 1-{1-[2-(4-Chloro-phenyl)-2-oxo-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one 
• 79098-91-2 1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 79098-90-1 1-benzyl-4-[N-(o-aminomethylphenyl)-amino]-piperidine 

Relevant articles and documents

Synthesis and evaluation of anticancer and PDE 5 inhibitory activity of spiro-substituted quinazolin-4-ones

A series of novel spiro-substituted 2,3-dihydroquinazolin-4(1H)-ones was synthesized and structurally confirmed by spectral analysis, screened for their anticancer activity at a concentration of 10 μΜ against a panel of 56 cell lines derived from nine different types of cancers, including leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers. The synthesized compounds screened for their PDE 5 inhibitory activity and it showed encouraged activity compared to sildenafil. Graphical abstract: [Figure not available: see fulltext.].

Facile method for the combinatorial synthesis of 2,2-Disubstituted Quinazolin-4(1 H)-one derivatives catalyzed by iodine in ionic liquids

A mild and facile method for the combinatorial synthesis of quinazolin-4-(1H)-one derivatives, containing simple 2,2-disubstituted quinazolin-4-(1H)-ones, spirocyclic quinazolin-4-(1H)-ones, spiro-heterocyclic quinazolin-4-(1H)-ones, and dispirocyclic quinazolin-4-(1H)-ones, is described, which results in high yields by using ionic liquids as green media. The method involves the reaction of 2-aminobenzamides with various ketones catalyzed by iodine and provides new quinazolin-4-(1H)-one library for biomedical screening.

Synthesis of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as potential antihypertensive agents

A series of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3- quinazolinyl)piperidine (KF5908) seemed the most promising.