98796-94-2

Upstream product

• 4778-84-1 N-(4-methylphenyl)isoindolinone 
• 68-12-2 N,N-dimethyl-formamide 
• 131119-95-4 2,3-dihydro-3-methylene-2-(4'-methylphenyl)-1H-isoindolone 
• 198020-51-8 2-[(2'-trimethylsilylethynyl)-N-p-methylphenyl]benzamide 
• 118-92-3 anthranilic acid 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 62303-05-3 2-iodo-N-(p-tolyl)benzamide 

Relevant academic research and scientific papers

Palladium-catalysed heteroannulation with terminal alkynes: A highly regio- and stereoselective synthesis of (Z)-3-aryl(alkyl)idene isoindolin-1- ones

A highly regio- and stereoselective method for the synthesis of (Z)-3- aryl(alkyl)idene isoindolin-1-ones through palladium-copper catalysis is described. 2-Iodobenzamide 1 and its substituted derivatives 2-10 were reacted with terminal alkynes 11-19 in the presence of (PPh3)2PdCl2, CuI, and Et3N in DMF mostly at 80°C for 16 h to yield the 2-alkynyl substituted benzamides 20-38, 40-45, 77 which could then be cyclised with NaOEt in EtOH to the 3-aryl(alkyl)idene isoindolin-1-ones 46-49, 51, 53-55, 57, 59-71, 73 and 75. In certain cases, the isoindolin-1-ones 50, 52, 56 and 58 could be directly obtained by the palladium-catalysed reactions. (C) 2000 Elsevier Science Ltd.