98832-93-0Relevant academic research and scientific papers
Newer substituted benzoxazepinyl-quinazolinones as potent antipsychotic and anticonvulsant agents
Bajaj, Kiran,Srivastava, Virendra Kishor,Kumar, Ashok
, p. 480 - 485 (2007/10/03)
3-Amino-[2′-substitutedaryl- 3′substitutedarylaminomethylene-2′,3′-dihydro- 1′,5′- benzoxazepin- 4′-yl]- 2- methyl-quinazolin- 4(3H)- ones 11-18 and 3-amino[2′-substituted aryl-3′-substitutedarylazo-2′,3′-dihydro-1′, 5′-benzoxazepin-4′-yl]-2-methyl-quinazolin-4(3H)-ones 19-26 were synthesized from 3-amino-[2′-substitutedaryl-2′,3′- dihydro-1′,5′-benzoxazepin-4′-yl]-2-methyl- quinazolin-4(3H)-ones 7-10 by Mannich's reaction and by diazotisation, respectively, on the 3rd position of the benzoxazepine ring of the compounds 7-10. The newly synthesized compounds showed potent antipsychotic and anticonvulsant activities.
Synthesis of potential quinazolinonyl pyrazolines and quinazolinyl isoxazolines as anticonvulsant agents
Archana,Srivastava,Chandra, Ramesh,Kumar, Ashok
, p. 2371 - 2375 (2007/10/03)
A series of 1-[3′-amino-2′-methyl-6′-monosubstitutedquinazolin- 4′(3′H)-onyl]-3-(arylidenyl)chalcones 3 have been synthesized via condensation of 3-acetylamino-2-methyl-6-monosubstitutedquinazolin-4(3H)-ones 2 with various aromatic aldehydes. Cycloaddition of hydrazine hydrate with 3 yields 1-acetyl-5-substitutedaryl-3-(3′-amino-2′-methyl-6′- monosubstitutedquinazolin-4′(3′H)-onyl]-2-pyrazolines 4 and cyclocondensation of hydroxylamine hydrochloride with 3 affords 5-substitutedaryl-3-[3′-amino-2′-methyl-6′- monosubstitutedquinazolin-4′-(3′H)-onyl]-isoxazolines 5. Compound 4g and 5g show most potent activity (90%) more potent than standard drug phenytoin sodium (80%).
Synthesis ans Biological Evaluation of Some New Fused Quinzoline Derivatives
Ibrahim, S. S.,Abdel-Halim, A. M.,Gabr, Y.,El-Edfawy, S.,Abdel-Rahman, R. M.
, p. 1041 - 1063 (2007/10/03)
Some new fused quinazoline derivatives have been prepared by reacting 3-N-acyl / aroylamino quinazolin-4(3)-ones (2) with different nucleophilic reagents.The structural assignments of all the new products were based on elemental analysis and chemical and spectroscopic data, and somw of the products have been screened for their antimicrobial activity. - Key Words: synthesis; biological; fused quinazolines
Synthesis and Pharmacological Activity of Some New 4(3H)-Quinazolone Derivatives
Ossman, Abdel Rahman El Nasser,Safwat, H. M.,Aziza, Mohsen A.
, p. 333 - 335 (2007/10/02)
New derivatives of 2-methyl-4(3H)-quinazolone have been prepared and their structures assigned on the basis of IR, PMR and mass spectra.Some of them show CNS depressant activity.
