98844-05-4

Upstream product

• 59-48-3 2-oxoindole 
• 61-70-1 N-methyl-2-indolinone 
• 93-55-0 1-phenyl-propan-1-one 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 

Downstream Products

• 1024796-29-9 (3S,3'R,3a'S,7'S)-1,3'-dimethyl-7'-phenyl-6',7'-dihydro-3'H-spiro[indole-3,2'-isoxazolo[3,2-c][1,4]oxazine]-2,4'(1H,3a'H)-dione 
• 1024796-33-5 (2'R,3S,3a'S,7'S)-1,2'-dimethyl-7'-phenyl-6',7'-dihydrospiro[indole-3,3'-isoxazolo[3,2-c][1,4]oxazine]-2,4'(1H,3a'H)-dione 

Relevant academic research and scientific papers

Autoxidation/Aldol Tandem Reaction of 2-Oxindoles with Ketones: A Green Approach for the Synthesis of 3-Hydroxy-2-Oxindoles

In the presence of tetrabutylammonium fluoride and molecular sieves (MS) 4 ? in DMF, an efficient autoxidation reaction of 2-oxindoles with ketones under air at room temperature has been developed. This approach may provide a green, practical, and metal-free protocol for a wide range of biologically important 3-hydroxy-3-(2-oxo-alkyl)-2-oxindoles.

Total synthesis of maremycins A and D1 using chiral and cyclic nitrone with (E)-3-ethylidene-1-methylindolin-2-one

Total syntheses of maremycin A (4) and maremycin D1 (8) were described, featuring 1,3-dipolar cycloaddition of a chiral cyclic nitrone 15 with (E)-3-ethylidene-1-methylindolin-2-one (13). The cycloaddition was reversible, especially at high temperature in the presence of a Lewis acid or in a solvent possessing a high acceptor number. One of the cycloadducts was efficiently led to maremycin A (4) and maremycin D1 (8). High optical purity of 4 was confirmed by chiral HPLC comparison with ent-4 prepared from ent-15 and 13.