98875-19-5

Upstream product

• 98875-28-6 (2R,3R,4aR,8aR)-3-Hydroxy-2-hydroxymethyl-7-methyl-4-oxo-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester 
• 98-09-9 benzenesulfonyl chloride 
• 98875-29-7 (2R,3S,4S,4aS,8aR)-4-Dimethylcarbamoylmethyl-3-hydroxy-2-hydroxymethyl-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester 
• 98875-16-2 (2R,3R,4aR,8aR)-3-Acetoxy-2-acetoxymethyl-7-methyl-4-oxo-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester 

Downstream Products

• 98875-20-8 (1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester 
• 98875-21-9 (1R,2S,7R,9R,11R,12S)-11-Acetyl-12-benzyloxy-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

A Route to Optically Active Trichothecane Skeleton by Bisannulation of a Pyranose Derivative

A process has been developed for bisannulation of a pyranose ring to produce the trichothecene skeleton in which (a) the cyclohexeno (A) ring is connected at C1/C2 of the sugar, (b) an Eschenmoser-Claisen rearrangement is applied at C3 to generate an equatorially oriented acetamido unit, and (c) the activated methylene group is used to displace a sulfonate at C6 of the original sugar in a process that forms the C ring.