98897-14-4 Usage
Description
N(6)-hydroxymethyladenosine, also known as N6-(Hydroxymethyl)adenosine, is an intermediate with modified ribonucleoside formed by chemical oxidation of N6-methyladenosine (M275895) mediated by bicarbonate-activated hydrogen peroxide. It is also reported as an active mutagen.
Uses
Used in Pharmaceutical Industry:
N(6)-hydroxymethyladenosine is used as a pharmaceutical intermediate for the synthesis of various nucleoside analogs and antiviral agents. Its unique chemical structure allows it to be a promising candidate for the development of new drugs targeting viral replication and other diseases.
Used in Genetic Research:
N(6)-hydroxymethyladenosine is used as a mutagen in genetic research to study the effects of mutations on gene expression and regulation. Its ability to induce mutations can help researchers understand the mechanisms of gene regulation and the role of specific genes in various biological processes.
Used in Biochemical Analysis:
N(6)-hydroxymethyladenosine is used as a biochemical marker in the analysis of nucleic acid modifications and their role in various cellular processes. Its detection and quantification can provide valuable insights into the mechanisms of gene regulation and the role of modified nucleosides in cellular function.
Check Digit Verification of cas no
The CAS Registry Mumber 98897-14-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,8,9 and 7 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 98897-14:
(7*9)+(6*8)+(5*8)+(4*9)+(3*7)+(2*1)+(1*4)=214
214 % 10 = 4
So 98897-14-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N5O5/c17-1-5-7(19)8(20)11(21-5)16-3-14-6-9(15-4-18)12-2-13-10(6)16/h2-3,5,7-8,11,17-20H,1,4H2,(H,12,13,15)/t5-,7-,8-,11-/m1/s1
98897-14-4Relevant articles and documents
1H and 13C NMR Study of the Interactions of Formaldehyde on Adenine and its Derivatives
Botlan, D. J. Le
, p. 295 - 298 (1989)
It has previously been shown the formaldehyde causes the formation of hydroxymethylated derivatives with nucelobases, buth these were identified after separationn of reaction products; such handling might destroy labile derivatives or remove products present in small proportions.This work is based on a study of the reactivity of formaldehyde on adenine, adenosine and adenosine monophosphate in the reaction medium.It demonstrates the high reactivity of the N-9 site of adenine, the reactivity of the hydroxymethyl at the C-5' of the ribose and brings to light such new derivatives as N-9-CH2OCH2OH and N-6-CH2OCH2OH.Further, the order of appearence of different derivetives and their approximate determination were achieved. KEY WORDS Formaldehyde Adenine Adenosine Adenosine monophosphate
