98901-16-7

Upstream product

• 3378-72-1 N-tert-butylbenzylamine 
• 103-80-0 phenylacetyl chloride 
• 6852-58-0 N-benzylidene tert-butylamine 
• 201230-82-2 carbon monoxide 
• 108-88-3 toluene 
• 27151-60-6 1-t-butyl-3-phenylaziridin-2-one 
• 1589-82-8 phenylmagnesium bromide 

Relevant academic research and scientific papers

Palladium-catalyzed oxidative aminocarbonylation: A new entry to amides via C-H activation

A novel palladium-catalyzed oxidative aminocarbonylation reaction via C(sp3)-H activation was established, which provides a convenient and general method for the construction of arylacetamides via the carbonylation reaction of alkyl aromatics and amines. By using this protocol, the marketed drug ibuprofen could be easily obtained.

Reactions of 1-tert-Butyl-3-phenylaziridinone and α-Bromo-N-tert-butylphenylacetamide with Benzyl-Grignard Reagents

1-tert-Butyl-3-phenylaziridinone (1) reacts with benzyl halide Grignard reagents (Br and Cl) to give N-tert-butyl-2,3-diphenylpropanamide (4), N-tert-butyl-2-phenylacetamide (3), N-tert-butyl-2-o-tolyl-2-phenylacetamide (5), 1-(tert-butylamino)-1,3-diphenylpropan-2-one (7), N-benzyl-N-tert-butyl-2-phenylacetamide (6), and N-tert-butyl-2-halo-2-phenylacetamide (2, X = Br, Cl).The choice of solvent appears to determine the relative amounts of products 4 and 5.The bromo amide 2 reacts with the Grignard reagent to give 3, 4, 5, 6, and 7 and may be involved to some extentin the reaction of 1 with benzyl-Grignard reagents.The formation of 5 represents anew type of "abnormal" product from a reaction of the benzyl-Grignard reagent; however, this product appears to fit well into the mechanistic pattern established for prior examples.